BACE and γ-secretase characterization and their sorting as therapeutic targets to reduce amyloidogenesis

Neurochemical Research

Volumn 35, Issue 2, 2010, Pages 181-210

  Marks, Neville ^a,b   Berg, Martin J ^a  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

, , Secretases; APP trafficking; Autophagy; Endosomes; Exosomes; FAD; Lysosomes; SAD; Secretases

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; AMYLOID PRECURSOR PROTEIN INTRACELLUAR DOMAIN; AMYLOID PRECURSOR PROTEIN LIKE PROTEIN; ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; BETA SECRETASE; GAMMA SECRETASE; LIPOPROTEIN RECEPTOR; MEMBRANE PROTEIN; NICASTRIN; PRESENILIN 1; PRESENILIN 2; PRESENILIN ENHANCER 2; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AUTOPHAGY; COMPLEX FORMATION; ENDOSOME; ENZYME INHIBITION; ENZYME SPECIFICITY; EXOSOME; HUMAN; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; REVIEW; SIGNAL TRANSDUCTION; VASCULAR AMYLOIDOSIS;

ADAM PROTEINS; ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; ASPARTIC ACID PROTEASES; AUTOPHAGY; CEREBRAL AMYLOID ANGIOPATHY; DRUG DESIGN; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; PRESENILINS; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY;

EID: 76849098161     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-009-0054-1     Document Type: Review

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