Nicastrin, presenilin, APH-1, and PEN-2 form active γ-secretase complexes in mitochondria

Journal of Biological Chemistry

Volumn 279, Issue 49, 2004, Pages 51654-51660

  Hansson, Camilla A ^a   Frykman, Susanne ^a   Farmery, Mark R ^a   Tjernberg, Lars O ^a   Nilsberth, Camilla ^a   Pursglove, Sharon E ^b   Ito, Akira ^c   Winblad, Bengt ^a   Cowburn, Richard F ^a   Thyberg, Johan ^a   Ankarcrona, Maria ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF SYDNEY   (Australia)

^c DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DISEASES; MICROSCOPIC EXAMINATION; NEUROLOGY; PROTEINS;

AMYLOID; MITOCHONDRIA;

OXIDATION;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; CELL PROTEIN; GAMMA SECRETASE; NICASTRIN; PRESENILIN 1; PROTEIN PEN2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; BRAIN TISSUE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; GENE SEQUENCE; GENE TARGETING; IMMUNOBLOTTING; IMMUNOELECTRON MICROSCOPY; MALE; MITOCHONDRION; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; RAT;

ADENOSINE TRIPHOSPHATE; ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; APOPTOSIS; ASPARTIC ENDOPEPTIDASES; BRAIN; CHOLIC ACIDS; DETERGENTS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOPEPTIDASES; ENDOPLASMIC RETICULUM; GOLGI APPARATUS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MICROSCOPY, IMMUNOELECTRON; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; NEURONS; OXIDATIVE STRESS; PEPTIDES; PRESENILIN-1; PROTEIN STRUCTURE, TERTIARY; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SUBCELLULAR FRACTIONS;

ANIMALIA;

EID: 19944373389     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M404500200     Document Type: Article

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