Accelerated plaque accumulation, associative learning deficits, and up-regulation of α7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins

Journal of Biological Chemistry

Volumn 277, Issue 25, 2002, Pages 22768-22780

  Dineley, Kelly T ^a,b,c,d   Xia, Xuefeng ^d   Bui, Duy ^a,b   David Sweatt, J ^a,d   Zheng, Hui ^a,c,d  

^a Division of Neuroscience   (United States)

^b Department of Molecular Physiology and Biophysics ^*  (United States)

^c Huffington Center on Aging   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; PROTEINS;

PLAQUE ACCUMULATION;

BIOCHEMISTRY;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; NICOTINIC RECEPTOR; PRESENILIN 1; PRESENILIN 2;

ADOLESCENT; AGED; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASSOCIATION; CONDITIONING; CONTROLLED STUDY; DENTATE GYRUS; FEAR; FEMALE; GENE EXPRESSION; HIPPOCAMPUS; LEARNING DISORDER; MALE; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR UPREGULATION; SENILE PLAQUE; STATE DEPENDENT LEARNING; TRANSGENIC MOUSE;

AGE FACTORS; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BEHAVIOR, ANIMAL; FEAR; HIPPOCAMPUS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LEARNING; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MUTATION; PRESENILIN-1; PROTEIN BINDING; RECEPTORS, NICOTINIC; SHOCK; TIME FACTORS; TRANSGENES; UP-REGULATION;

ANIMALIA; MUS MUSCULUS;

EID: 0037151046     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M200164200     Document Type: Article

References (36)