메뉴 건너뛰기




Volumn 8, Issue 7, 2006, Pages 688-698

Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; MULTIPROTEIN COMPLEX; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN UVRAG; SMALL INTERFERING RNA; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

EID: 33745751085     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1426     Document Type: Article
Times cited : (892)

References (39)
  • 1
    • 19944434059 scopus 로고    scopus 로고
    • Inhibition of macroautophagy triggers apoptosis
    • Boya, P. et al. Inhibition of macroautophagy triggers apoptosis. Mol. Cell Biol. 25, 1025-1040 (2005).
    • (2005) Mol. Cell Biol. , vol.25 , pp. 1025-1040
    • Boya, P.1
  • 2
    • 14044277429 scopus 로고    scopus 로고
    • The molecular machinery of autophagy: Unanswered questions
    • Klionsky, D. J. The molecular machinery of autophagy: Unanswered questions. J. Cell Sci. 118, 7-18 (2005).
    • (2005) J. Cell Sci. , vol.118 , pp. 7-18
    • Klionsky, D.J.1
  • 3
    • 12944308330 scopus 로고    scopus 로고
    • Eating oneself and uninvited guests: Autophagy-related pathways in cellular defense
    • Levine, B. Eating oneself and uninvited guests: Autophagy-related pathways in cellular defense. Cell 120, 159-162 (2005).
    • (2005) Cell , vol.120 , pp. 159-162
    • Levine, B.1
  • 4
    • 1842583789 scopus 로고    scopus 로고
    • Development by self-digestion: Molecular mechanisms and biological functions of autophagy
    • Levine, B. & Klionsky, D. J. Development by self-digestion: Molecular mechanisms and biological functions of autophagy. Dev. Cell 6, 463-477 (2004).
    • (2004) Dev. Cell , vol.6 , pp. 463-477
    • Levine, B.1    Klionsky, D.J.2
  • 6
    • 0035809160 scopus 로고    scopus 로고
    • Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae
    • Kihara, A., Noda, T., Ishihara, N. & Ohsumi, Y. Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J. Cell Biol. 152, 519-530 (2001).
    • (2001) J. Cell Biol. , vol.152 , pp. 519-530
    • Kihara, A.1    Noda, T.2    Ishihara, N.3    Ohsumi, Y.4
  • 7
    • 0035503594 scopus 로고    scopus 로고
    • The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation
    • Suzuki, K. et al. The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation. EMBO J. 20, 5971-5981 (2001).
    • (2001) EMBO J. , vol.20 , pp. 5971-5981
    • Suzuki, K.1
  • 8
    • 39049194057 scopus 로고    scopus 로고
    • The evolutionarily conserved domain of beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function
    • Furuya N., Yu J., Byfield M., Pattingre S & B., L. The evolutionarily conserved domain of beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function. Autophagy 1, 46-52 (2005).
    • (2005) Autophagy , vol.1 , pp. 46-52
    • Furuya, N.1    Yu, J.2    Byfield, M.3    Pattingre, S.B.L.4
  • 9
    • 0344142468 scopus 로고    scopus 로고
    • Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21
    • Aita, V. M. et al. Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. Genomics 59, 59-65 (1999).
    • (1999) Genomics , vol.59 , pp. 59-65
    • Aita, V.M.1
  • 10
    • 0000906170 scopus 로고    scopus 로고
    • Induction of autophagy and inhibition of tumorigenesis by beclin 1
    • Liang, X. H. et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 402, 672-676 (1999).
    • (1999) Nature , vol.402 , pp. 672-676
    • Liang, X.H.1
  • 11
    • 9144240441 scopus 로고    scopus 로고
    • Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
    • Qu, X. et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J. Clin. Invest. 112, 1809-1820 (2003).
    • (2003) J. Clin. Invest. , vol.112 , pp. 1809-1820
    • Qu, X.1
  • 12
    • 0345166111 scopus 로고    scopus 로고
    • Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
    • Yue, Z., Jin, S., Yang, C., Levine, A. J. & Heintz, N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc. Natl Acad. Sci. USA 100, 15077-15082 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 15077-15082
    • Yue, Z.1    Jin, S.2    Yang, C.3    Levine, A.J.4    Heintz, N.5
  • 13
    • 2442482810 scopus 로고    scopus 로고
    • Autophagy as a cell death and tumor suppressor mechanism
    • Gozuacik, D. & Kimchi, A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene 23, 2891-2906 (2004).
    • (2004) Oncogene , vol.23 , pp. 2891-2906
    • Gozuacik, D.1    Kimchi, A.2
  • 14
    • 0030883558 scopus 로고    scopus 로고
    • Inhibition of autophagy abrogates tumour necrosis factor alpha induced apoptosis in human T-lymphoblastic leukaemic cells
    • Jia, L. et al. Inhibition of autophagy abrogates tumour necrosis factor alpha induced apoptosis in human T-lymphoblastic leukaemic cells. Br. J. Haematol. 98, 673-685 (1997).
    • (1997) Br. J. Haematol. , vol.98 , pp. 673-685
    • Jia, L.1
  • 15
    • 1542513774 scopus 로고    scopus 로고
    • Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro
    • Mills, K. R., Reginato, M., Debnath, J., Queenan, B. & Brugge, J. S. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro. Proc. Natl Acad. Sci. USA 101, 3438-3443 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 3438-3443
    • Mills, K.R.1    Reginato, M.2    Debnath, J.3    Queenan, B.4    Brugge, J.S.5
  • 16
    • 14844310233 scopus 로고    scopus 로고
    • Selective inactivation of a Fas-associated death domain protein (FADD)-dependent apoptosis and autophagy pathway in immortal epithelial cells
    • Thorburn, J. et al. Selective inactivation of a Fas-associated death domain protein (FADD)-dependent apoptosis and autophagy pathway in immortal epithelial cells. Mol. Biol. Cell 16, 1189-1199 (2005).
    • (2005) Mol. Biol. Cell , vol.16 , pp. 1189-1199
    • Thorburn, J.1
  • 17
    • 0035929650 scopus 로고    scopus 로고
    • The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway
    • Arico, S. et al. The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway. J. Biol. Chem. 276, 35243-35246 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 35243-35246
    • Arico, S.1
  • 18
    • 25144457455 scopus 로고    scopus 로고
    • Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
    • Pattingre, S. et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 122, 927-939 (2005).
    • (2005) Cell , vol.122 , pp. 927-939
    • Pattingre, S.1
  • 19
    • 10344262564 scopus 로고    scopus 로고
    • Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes
    • Shimizu, S. et al. Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nature Cell Biol. 6, 1221-1228 (2004).
    • (2004) Nature Cell Biol. , vol.6 , pp. 1221-1228
    • Shimizu, S.1
  • 20
    • 0030738667 scopus 로고    scopus 로고
    • Complete sequence and genomic analysis of murine gammaherpesvirus 68
    • Virgin, H. W. t. et al. Complete sequence and genomic analysis of murine gammaherpesvirus 68. J. Virol. 71, 5894-5904 (1997).
    • (1997) J. Virol. , vol.71 , pp. 5894-5904
    • Virgin, H.W.T.1
  • 21
    • 1442301767 scopus 로고    scopus 로고
    • Viral Bcl-2 homologs and their role in virus replication and associated diseases
    • Polster, B. M., Pevsner, J. & Hardwick, J. M. Viral Bcl-2 homologs and their role in virus replication and associated diseases. Biochim. Biophys. Acta. 1644, 211-227 (2004).
    • (2004) Biochim. Biophys. Acta. , vol.1644 , pp. 211-227
    • Polster, B.M.1    Pevsner, J.2    Hardwick, J.M.3
  • 22
    • 0034517673 scopus 로고    scopus 로고
    • Murine gammaherpesvirus M11 gene product inhibits apoptosis and is expressed during virus persistence
    • Roy, D. J., Ebrahimi, B. C., Dutia, B. M., Nash, A. A. & Stewart, J. P. Murine gammaherpesvirus M11 gene product inhibits apoptosis and is expressed during virus persistence. Arch. Virol. 145, 2411-2420 (2000).
    • (2000) Arch. Virol. , vol.145 , pp. 2411-2420
    • Roy, D.J.1    Ebrahimi, B.C.2    Dutia, B.M.3    Nash, A.A.4    Stewart, J.P.5
  • 23
    • 0032861298 scopus 로고    scopus 로고
    • The murine gammaherpesvirus-68 M11 protein inhibits Fas- and TNF-induced apoptosis
    • Wang, G. H., Garvey, T. L. & Cohen, J. I. The murine gammaherpesvirus-68 M11 protein inhibits Fas- and TNF-induced apoptosis. J. Gen. Virol. 80, 2737-2740 (1999).
    • (1999) J. Gen. Virol. , vol.80 , pp. 2737-2740
    • Wang, G.H.1    Garvey, T.L.2    Cohen, J.I.3
  • 24
    • 11444254723 scopus 로고    scopus 로고
    • Murine gammaherpesvirus 68 bcl-2 homologue contributes to latency establishment in vivo
    • de Lima, B. D., May, J. S., Marques, S., Simas, J. P. & Stevenson, P. G. Murine gammaherpesvirus 68 bcl-2 homologue contributes to latency establishment in vivo. J. Gen. Virol. 86, 31-40 (2005).
    • (2005) J. Gen. Virol. , vol.86 , pp. 31-40
    • de Lima, B.D.1    May, J.S.2    Marques, S.3    Simas, J.P.4    Stevenson, P.G.5
  • 26
    • 2642642963 scopus 로고    scopus 로고
    • Detailed map of a region commonly amplified at 11q13→q14 in human breast carcinoma
    • Bekri, S. et al. Detailed map of a region commonly amplified at 11q13→q14 in human breast carcinoma. Cytogenet. Cell. Genet. 79, 125-131 (1997).
    • (1997) Cytogenet. Cell. Genet. , vol.79 , pp. 125-131
    • Bekri, S.1
  • 27
    • 0031149239 scopus 로고    scopus 로고
    • Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus
    • Perelman, B. et al. Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus. Genomics 41, 397-405 (1997).
    • (1997) Genomics , vol.41 , pp. 397-405
    • Perelman, B.1
  • 28
    • 0042836544 scopus 로고    scopus 로고
    • Ascending colon cancer with hepatic metastasis and cholecystolithiasis in a patient with situs inversus totalis without any expression of UVRAG mRNA: Report of a case
    • Goi, T. et al. Ascending colon cancer with hepatic metastasis and cholecystolithiasis in a patient with situs inversus totalis without any expression of UVRAG mRNA: Report of a case. Surg. Today 33, 702-706 (2003).
    • (2003) Surg. Today , vol.33 , pp. 702-706
    • Goi, T.1
  • 29
    • 1242296021 scopus 로고    scopus 로고
    • Manipulation of nonsense mediated decay identifies gene mutations in colon cancer cells with microsatellite instability
    • Ionov, Y., Nowak, N., Perucho, M., Markowitz, S. & Cowell, J. K. Manipulation of nonsense mediated decay identifies gene mutations in colon cancer cells with microsatellite instability. Oncogene 23, 639-645 (2004).
    • (2004) Oncogene , vol.23 , pp. 639-645
    • Ionov, Y.1    Nowak, N.2    Perucho, M.3    Markowitz, S.4    Cowell, J.K.5
  • 30
    • 0001488499 scopus 로고    scopus 로고
    • Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein
    • Liang, X. H. et al. Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J. Virol. 72, 8586-8596 (1998).
    • (1998) J. Virol. , vol.72 , pp. 8586-8596
    • Liang, X.H.1
  • 31
    • 33745756937 scopus 로고    scopus 로고
    • A surface groove essential for viral bcl-2 function during chronic infection in vivo
    • Loh, J. et al. A surface groove essential for viral bcl-2 function during chronic infection in vivo. PLoS Pathog. 1, e10 (2005).
    • (2005) PLoS Pathog. , vol.1
    • Loh, J.1
  • 33
    • 1542283812 scopus 로고    scopus 로고
    • In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker
    • Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T. & Ohsumi, Y. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol. Biol. Cell 15, 1101-1111 (2004).
    • (2004) Mol. Biol. Cell , vol.15 , pp. 1101-1111
    • Mizushima, N.1    Yamamoto, A.2    Matsui, M.3    Yoshimori, T.4    Ohsumi, Y.5
  • 34
    • 0034329418 scopus 로고    scopus 로고
    • LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
    • Kabeya, Y. et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 19, 5720-5728 (2000).
    • (2000) EMBO J. , vol.19 , pp. 5720-5728
    • Kabeya, Y.1
  • 35
    • 0035494493 scopus 로고    scopus 로고
    • Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation
    • Vieira, O. V. et al. Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation. J. Cell Biol. 155, 19-25 (2001).
    • (2001) J. Cell Biol. , vol.155 , pp. 19-25
    • Vieira, O.V.1
  • 36
    • 25144506835 scopus 로고    scopus 로고
    • Autophagy in cell death: An innocent convict?
    • Levine, B. & Yuan, J. Autophagy in cell death: An innocent convict? J. Clin. Invest. 115, 2679-2688 (2005).
    • (2005) J. Clin. Invest. , vol.115 , pp. 2679-2688
    • Levine, B.1    Yuan, J.2
  • 37
    • 0034030932 scopus 로고    scopus 로고
    • Identification of a gene disrupted by inv(11)(q13.5;q25) in a patient with left-right axis malformation
    • Iida, A. et al. Identification of a gene disrupted by inv(11)(q13.5;q25) in a patient with left-right axis malformation. Hum. Genet. 106, 277-287 (2000).
    • (2000) Hum. Genet. , vol.106 , pp. 277-287
    • Iida, A.1
  • 38
    • 12944303650 scopus 로고    scopus 로고
    • Growth factor regulation of autophagy and cell survival in the absence of apoptosis
    • Lum, J. J. et al. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120, 237-248 (2005).
    • (2005) Cell , vol.120 , pp. 237-248
    • Lum, J.J.1
  • 39
    • 26444575415 scopus 로고    scopus 로고
    • Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
    • Nobukuni, T. et al. Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc. Natl Acad. Sci. USA 102, 14238-14243 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 14238-14243
    • Nobukuni, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.