Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the γ-secretase complex

Journal of Biological Chemistry

Volumn 279, Issue 22, 2004, Pages 23255-23261

  Prokop, Stefan ^a   Shirotani, Keiro ^a   Edbauer, Dieter ^a   Haass, Christian ^a   Steiner, Harald ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; CATALYSIS; DEGRADATION; DISEASES;

PRECURSOR PROTEINS; TRANSMEMBRANE PROTEINS;

BIOCHEMISTRY;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; MUTANT PROTEIN; NICASTRIN; PRESENILIN 1; PRESENILIN N; PROTEASOME; PROTEIN PEN 2; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MATURATION; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; EXON; EXPRESSED SEQUENCE TAG; HUMAN; HUMAN CELL; MUTANT; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STABILITY; RNA INTERFERENCE;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CELL LINE; CRICETINAE; DIMERIZATION; ENDOPEPTIDASES; HUMANS; HYDROLYSIS; MEMBRANE PROTEINS; PEPTIDE FRAGMENTS; PRESENILIN-1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 2542454942     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M401789200     Document Type: Article

References (48)

1. Haass, C., and Steiner, H. (2002) Trends Cell Biol. 12, 556-562
2. Selkoe, D. J. (2001) Physiol. Rev. 81, 741-766
3. Thinakaran, G., Borchelt, D. R., Lee, M. K., Slunt, H. H., Spitzer, L., Kim, G., Ratovitsky, T., Davenport, F., Nordstedt, C., Seeger, M., Hardy, J., Levey, A. I., Gandy, S. E., Jenkins, N. A., Copeland, N. G., Price, D. L., and Sisodia, S. S. (1996) Neuron 17, 181-190
4. Goutte, C., Hepler, W., Mickey, K. M., and Priess, J. R. (2000) Development 127, 2481-2492
5. Yu, G., Nishimura, M., Arawaka, S., Levitan, D., Zhang, L., Tandon, A., Song, Y. Q., Rogaeva, E., Chen, F., Kawarai, T., Supala, A., Levesque, L., Yu, H., Yang, D. S., Holmes, E., Milman, P., Liang, Y., Zhang, D. M., Xu, D. H., Sato, C., Rogaev, E., Smith, M., Janus, C., Zhang, Y., Aebersold, R., Farrer, L. S., Sorbi, S., Bruni, A., Fraser, P., and St George-Hyslop, P. (2000) Nature 407, 48-54
6. Francis, R., McGrath, G., Zhang, J., Ruddy, D. A., Sym, M., Apfeld, J., Nicoll, M., Maxwell, M., Hai, B., Ellis, M. C., Parks, A. L., Xu, W., Li, J., Gurney, M., Myers, R. L., Himes, C. S., Hiebsch, R. D., Ruble, C., Nye, J. S., and Curtis, D. (2002) Dev. Cell 3, 85-97
7. Goutte, C., Tsunozaki, M., Hale, V. A., and Priess, J. R. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 775-779
8. Hu, Y., Ye, Y., and Fortini, M. E. (2002) Dev. Cell 2, 69-78
9. Edbauer, D., Winkler, E., Haass, C., and Steiner, H. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 8666-8671
10. Leem, J. Y., Vijayan, S., Han, P., Cai, D., Machura, M., Lopes, K. O., Veselits, M. L., Xu, H., and Thinakaran, G. (2002) J. Biol. Chem. 277, 19236-19240
11. Steiner, H., Winkler, E., Edbauer, D., Prokop, S., Basset, G., Yamasaki, A., Kostka, M., and Haass, C. (2002) J. Biol. Chem. 277, 39062-39065
12. Lee, S. F., Shah, S., Li, H., Yu, C., Han, W., and Yu, G. (2002) J. Biol. Chem. 277, 45013-45019
13. Gu, Y., Chen, F., Sanjo, N., Kawarai, T., Hasegawa, H., Duthie, M., Li, W., Ruan, X., Luthra, A., Mount, H. T., Tandon, A., Fraser, P. E., and St. George-Hyslop, P. (2003) J. Biol. Chem. 278, 7374-7380
14. Luo, W. J., Wang, H., Li, H., Kim, B. S., Shah, S., Lee, H. J., Thinakaran, G., Kim, T. W., Yu, G., and Xu, H. (2003) J. Biol. Chem. 278, 7850-7854
15. Kimberly, W. T., LaVoie, M. J., Ostaszewski, B. L., Ye, W., Wolfe, M. S., and Selkoe, D. J. (2002) J. Biol. Chem. 277, 35113-35117
16. Herreman, A., Van Gassen, G., Bentahir, M., Nyabi, O., Craessaerts, K., Mueller, U., Annaert, W., and De Strooper, B. (2003) J. Cell Sci. 116, 1127-1136
17. Takasugi, N., Tomita, T., Hayashi, I., Tsuruoka, M., Niimura, M., Takahashi, Y., Thinakaran, G., and Iwatsubo, T. (2003) Nature 422, 438-441
18. Li, T., Ma, G., Cai, H., Price, D. L., and Wong, P. C. (2003) J. Neurosci. 23, 3272-3277
19. Nyabi, O., Bentahir, M., Horre, K., Herreman, A., Gottardi-Littell, N., Van Broeckhoven, C., Merchiers, P., Spittaels, K., Annaert, W., and De Strooper, B. (2003) J. Biol. Chem. 278, 43430-43436
20. Shirotani, K., Edbauer, D., Kostka, M., Steiner, H., and Haass, C. (2004) J. Neurochem., in press
21. Kimberly, W. T., LaVoie, M. J., Ostaszewski, B. L., Ye, W., Wolfe, M. S., and Selkoe, D. J. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 6382-6387
22. Kim, S. H., Ikeuchi, T., Yu, C., and Sisodia, S. S. (2003) J. Biol. Chem. 278, 33992-34002
23. Edbauer, D., Winkler, E., Regula, J. T., Pesold, B., Steiner, H., and Haass, C. (2003) Nat. Cell Biol. 5, 486-488
24. LaVoie, M. J., Fraering, P. C., Ostaszewski, B. L., Ye, W., Kimberly, W. T., Wolfe, M. S., and Selkoe, D. J. (2003) J. Biol. Chem. 278, 37213-37222
25. Morais, V. A., Crystal, A. S., Pijak, D. S., Carlin, D., Costa, J., Lee, V. M., and Doms, R. W. (2003) J. Biol. Chem. 278, 43284-43291
26. Shirotani, K., Edbauer, D., Capell, A., Schmitz, J., Steiner, H., and Haass, C. (2003) J. Biol. Chem. 278, 16474-16477
27. Cervantes, S., Gonzalez-Duarte, R., and Marfany, G. (2001) FEBS Lett. 505, 81-86
28. Schroeter, E. H., Ilagan, M. X., Brunkan, A. L., Hecimovic, S., Li, Y. M., Xu, M., Lewis, H. D., Saxena, M. T., De Strooper, B., Coonrod, A., Tomita, T., Iwatsubo, T., Moore, C. L., Goate, A., Wolfe, M. S., Shearman, M., and Kopan, R. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 13075-13080
29. Fraering, P. C., LaVoie, M. J., Ye, W., Ostaszewski, B. L., Kimberly, W. T., Selkoe, D. J., and Wolfe, M. S. (2004) Biochemistry 43, 323-333
30. Wolfe, M. S., Xia, W., Ostaszewski, B. L., Diehl, T. S., Kimberly, W. T., and Selkoe, D. J. (1999) Nature 398, 513-517
31. Steiner, H., Duff, K., Capell, A., Romig, H., Grim, M. G., Lincoln, S., Hardy, J., Yu, X., Picciano, M., Fechteler, K., Citron, M., Kopan, R., Pesold, B., Keck, S., Baader, M., Tomita, T., Iwatsubo, T., Baumeister, R., and Haass, C. (1999) J. Biol. Chem. 274, 28669-28673
32. Li, Y. M., Xu, M., Lai, M. T., Huang, Q., Castro, J. L., DiMuzio-Mower, J., Harrison, T., Lellis, C., Nadin, A., Neduvelli, J. G., Register, R. B., Sardana, M. K., Shearman, M. S., Smith, A. L., Shi, X. P., Yin, K. C., Shafer, J. A., and Gardell, S. J. (2000) Nature 405, 689-694
33. Esler, W. P., Kimberly, W. T., Ostaszewski, B. L., Diehl, T. S., Moore, C. L., Tsai, J.-Y., Rahmati, T., Xia, W., Selkoe, D. J., and Wolfe, M. S. (2000) Nat. Cell Biol. 2, 428-433
34. Weihofen, A., and Martoglio, B. (2003) Trends Cell Biol. 13, 71-78
35. LaPointe, C. F., and Taylor, R. K. (2000) J. Biol. Chem. 275, 1502-1510
36. Steiner, H., Kostka, M., Romig, H., Basset, G., Pesold, B., Hardy, J., Capell, A., Meyn, L., Grim, M. G., Baumeister, R., Fechteler, K., and Haass, C. (2000) Nat. Cell Biol. 2, 848-851
37. Weihofen, A., Binns, K., Lemberg, M. K., Ashman, K., and Martoglio, B. (2002) Science 296, 2215-2218
38. Steiner, H., Romig, H., Grim, M. G., Philipp, U., Pesold, B., Citron, M., Baumeister, R., and Haass, C. (1999) J. Biol. Chem. 274, 7615-7618
39. Walter, J., Grunberg, J., Capell, A., Pesold, B., Schindzielorz, A., Citron, M., Mendla, K., George-Hyslop, P. S., Multhaup, G., Selkoe, D. J., and Haass, C. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 5349-5354
40. Capell, A., Saffrich, R., Olivo, J. C., Meyn, L., Walter, J., Grunberg, J., Mathews, P., Nixon, R., Dotti, C., and Haass, C. (1997) J. Neurochem. 69, 2432-2440
41. Brummelkamp, T. R., Bernards, R., and Agami, R. (2002) Science 296, 550-553
42. Citron, M., Oltersdorf, T., Haass, C., McConlogue, L., Hung, A. Y., Seubert, P., Vigo-Pelfrey, C., Lieberbarg, I., and Selkoe, D. J. (1992) Nature 360, 672-674
43. Sastre, M., Steiner, H., Fuchs, K., Capell, A., Multhaup, G., Condron, M. M., Teplow, D. B., and Haass, C. (2001) EMBO Rep. 2, 835-841
44. Steiner, H., Capell, A., Pesold, B., Citron, M., Kloetzel, P. M., Selkoe, D. J., Romig, H., Mendla, K., and Haass, C. (1998) J. Biol. Chem. 273, 32322-32331
45. Dick, L. R., Cruikshank, A. A., Destree, A. T., Grenier, L., McCormack, T. A., Melandri, F. D., Nunes, S. L., Palombella, V. J., Parent, L. A., Plamondon, L., and Stein, R. L. (1997) J. Biol. Chem. 272, 182-188
46. Aberle, H., Bauer, A., Stappert, J., Kispert, A., and Kemler, R. (1997) EMBO J. 16, 3797-3804
47. Perez-Tur, J., Froelich, S., Prihar, G., Crook, R., Baker, M., Duff, K., Wragg, M., Busfield, F., Lendon, C., Clark, R. F., Roques, P., Fuldner, R. A., Johnston, J., Cowburn, R., Forsell, C., Axelman, K., Lilius, L., Houlden, H., Karran, E., Roberts, G. W., Rossor, M., Adams, M. D., Hardy, J., Goate, A., Lannfelt, L., and Hutton, M. (1995) Neuroreport 7, 297-301
48. Ratovitski, T., Slunt, H. H., Thinakaran, G., Price, D. L., Sisodia, S. S., and Borchelt, D. R. (1997) J. Biol. Chem. 272, 24536-24541