Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing

Nature

Volumn 407, Issue 6800, 2000, Pages 48-54

  Yu, Gang ^a,b,c   Nishimura, Masaki ^a,b,c,d   Arawaka, Shigeki ^a,b,c   Levitan, Diane ^d   Zhang, Lili ^d   Tandon, Anurag ^a,b,c   Song, You Qiang ^a,b,c   Rogaeva, Ekaterina ^a,b,c   Chen, Fusheng ^a,b,c   Kawarai, Toshitaka ^a,b,c   Supala, Agnes ^a,b,c   Levesque, Lyne ^a,b,c   Yu, Haung ^a,b,c   Yang, Dun Sheng ^a,b,c   Holmes, Erin ^a,b,c   Milman, Paul ^a,b,c   Liang, Yan ^a,b,c   Zhang, Dong Mel ^a,b,c   Xu, Dong Hong ^a,b,c   Sato, Christine ^a,b,c   Rogaev, Evgeny ^a,b,c   Smith, Marsha ^d   Janus, Christopher ^a,b,c   Zhang, Yanni ^e   Aebersold, Ruedl ^e   Farrer, Lindsay ^f   Sorbl, Sandro ^g   Bruni, Amalia ^h   Fraser, Paul ^a,b,c   George Hyslop, Peter St ^a,b,c   more..

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d MERCK RESEARCH LABORATORIES   (United States)

^e UNIVERSITY OF WASHINGTON   (United States)

^f BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF FLORENCE   (Italy)

^h Polo Pediatrico PO Casa del Sole   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; MEMBRANE PROTEIN; NICASTRIN; PRESENILIN 1; PRESENILIN 2; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CAENORHABDITIS ELEGANS; HUMAN; HUMAN CELL; HUMAN TISSUE; MISSENSE MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; DNA, COMPLEMENTARY; ENDOPEPTIDASES; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; PRESENILIN-1; PRESENILIN-2; RECEPTORS, NOTCH; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TRANSFECTION;

CAENORHABDITIS ELEGANS; HUMULUS; INVERTEBRATA; PROTOZOA;

EID: 0034618715     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35024009     Document Type: Article

References (44)

1. Sherrington, R. et al. Cloning of a gene hearing missense mutations in early onset familial Alzheimer's disease. Nature 375, 754-760 (1995).
2. Rogaev, E. I. et al. Familial Alzheimer's disease in kindreds with missense mutations in a novel gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376, 775-778 (1995).
3. Yu, G. et al. The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains β-catenin. J. Biol. Chem. 273, 16470-16475 (1998).
4. Nishimura, M. et al. Presenilin mutations dominantly modulate β-catenin trafficking. Nature Med. 5, 164-169 (1999).
5. De Strooper, B. et al. Post-translational modification, subcellular localization and membrane orientation of the Alzheimer's Disease associated Presenilins. J. Biol. Chem 272, 3590-3598 (1997).
6. De Strooper, B. et al. Deficiency of presenilin 1 inhibits the normal cleavage of amyloid precursor protein. Nature 391, 387-390 (1998).
7. Ye, Y., Lukinova, N & Fortini, M. E. Neurogenic phenotypes and altered Notch processing in Drosophila presenilin mutants. Nature 398, 525-529 (1999).
8. Struhl, G. & Greenwald, I. Presenilin is required for activity and nuclear access of Notch in Drosophila. Nature 398, 522-525 (1999).
9. De Strooper B. et al. A presenilin dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature 398, 518-522 (1999).
10. Song, W. et al. Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations. Proc. Natl Acad. Sci. USA 96, 6959-6963 (1999).
11. Katayama, T. et al. Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response. Nature Cell Biol. 1, 479-485 (1999).
12. Niwa, M., Sidrauski, C., Kaufman, R. J. & Walter, P. A role for presenilin-1 in nuclear accumulation of lrel fragments amd induction of the mammalian Unfolded Protein Response. Cell 99, 691-702 (1999).
13. Scheuner, D. et al. Secreted amyloid-β protein similar to that in the senile plaques of Alzheimer Disease is increased in vivo by presenilin 1 and 2 and APP mutations linked to FAD. Nature Med. 2, 864-870 (1990).
14. Citron, M. et al. Mutant presenilins of Alzheimer's Disease increase production of 42 residue amyloid β-protein in both transfected cells and transgenic mice. Nature Med. 3, 67-72 (1997).
15. Wolfe, M. S. et al. Two transmembrane aspartates in presenilin 1 required for presenilin endoproteolysis and gamma-secretase activity. Nature 398, 513-517 (1999).
16. Li, Y. M. et al. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1. Nature 405, 689-694 (2000).
17. Thinakaran, G. et al. Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors. J. Biol. Chem. 272, 28415-28422 (1997).
18. Li, Y.-M. et al. Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state. Proc. Natl Acad. Sci. USA 97, 6138-6143 (2000).
19. Yu, G. Mutation of conserved aspartates affect maturation of both aspartate-mutant and endogenous presenilin 1 and presenilin 2 Complexes. J. Biol. Chem. (in the press).
20. Feldman, R. G., Chandler, K. A., Levy, L. L. & Glaser, G. H. Familial Alzheimer's Disease. Neurology 13, 811-824 (1963).
21. Foncin, J.-F. et al. Démence présénile d'Alzheimer transmise dans une famille étendue. Rev. Neurol. (Paris) 141, 194-202 (1985).
22. Figeys, D., Ducret, A., Yates, J. R. & Aebersold, R. Protein identification by solid phase micro-extraction-capillary zone electrophoresis-microelectrospray-tandem mass spectroscopy. Nature Biotech. 14, 1579-1583 (1996).
23. Zhou, J. et al. Presenilin 1 interacts with a novel member of the armadillo family. NeuroReport 8, 2085-2090 (1997).
24. Levesque, G. et al. Presenilins interact with armadillo proteins including neural specific plakophilin related protein and beta-catenin. J. Neurochem. 72, 999-1008 (1999).
25. Kehoe, P. et al. A full genome scan for late onset Alzheimer's Disease. Hum. Mol. Genet. 8, 237-245 (1999).
26. Zubenko, G. S., Hughes, H. B., Stiffler, J. S., Hurtt, M. R. & Kaplan, B. B. A genome survey for novel Alzheimer disease risk loci: results at 10 cM resolution. Genomics 50, 121-128 (1998).
27. Preiss, J. R., Schnabel, H. & Schnabel, R. The glp-1 locus and cellular interactions in early C. elegans embryos. Cell 51, 601-611 (1987).
28. Li, X & Greenwald, I. HOP-1, A Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL12 presenilin and to facilitate LIN-12 and GLP-1 signalling. Proc. Natl Acad. Sci. USA 94, 12204-12209 (1998).
29. Westlund, B., Barry, D, Clover, R., Basson, M. & Johnson, C. D. Reverse genetic analysis of C. elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling. Proc. Natl Acad. Sci. USA 96, 2497-2502 (1999).
30. Goutte, C., Hepler, W., Mickey, K. M. & Priess, J. R. aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling. Development 127, 2481-2492 (2000).
31. Hussain, I. et al. Identification of a novel aspartic protease (Asp 2) as beta-secretase. Mol. Cell Neurosci. 14, 419-427 (1999).
32. Sinha, S. et al. Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature 402, 537-540 (1999).
33. Vassar, R. et al. Beta-secretase cleavage of Alzheimer's Amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286, 735-741 (1999).
34. Van, R. et al. Membrane-anchored aspartyl protease with Alzheimer's Disease beta-secretase activity. Nature 402, 533-537 (1999).
35. Selkoe, D. J. Normal and abnormal biology of β-Amyloid Precursor Protein. Ann. Rev. Neurosci. 17, 489-517 (1994).
36. Xia, W., Zhang, J., Perez, R., Koo, E. H. & Selkoe, D. J. Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer Disease. Proc. Natl Acad. Sci. USA 94, 820S-8213 (1997).
37. Ray, W. J. et al. Evidence for a physical interaction between presenilin and Notch. Proc. Natl Acad. Sci. USA 96, 3263-3268 (1999).
38. Thinakaran, G. et al. Stable association of the presenilin derivatives and absence of presenilin interactions with APP. Neurobiol. Disease 4, 438-453 (1998).
39. Capell, A. et al. The proteolytic fragments of the Alzheimer's Disease associated presenilin-1 form heterodimers and occur as a 100-150 kDa molecular mass complex, J. Biol. Chem. 273, 3205-3211 (1998).
40. Hay, J. C., Chao, D. S., Kuo, C. S. & Scheller, R. H. Protein interaction regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells. Cell 89, 149-158 (1997).
41. Citron, M. et al. Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein. Neurobiol. Dis. 5, 107-116 (1998).
42. Chen, F. Proteolytic derivative of Amyloid Precursor Protein accumulate in restricted and unpredicted intracellular compartments in the absence of functional presenilin 1 expression. J. Biol. Chem. (in the press).
43. Zhjng, L., Song, L. & Parker, E. M. Calpain inhibitor 1 increases beta-Amyloid peptide production by inhibiting the degradation of the substrate of gamma-secretase. J. Biol. Chem. 274, 8966-8972 (1999).
44. Howell, D. C. Statistical Methods for Psychology (Duxbury Press, California, 1992).