Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: Association with Fe65 and translocation to the nucleus

Journal of Neurochemistry

Volumn 82, Issue 4, 2002, Pages 839-847

  Kinoshita, A ^a   Whelan, C M ^a   Smith, C J ^a   Berezovska, O ^a   Hyman, B T ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Alzheimer Research Unit   (United States)

Author keywords

Adapter protein; Amyloid precursor protein; Fe65; FRET; Gamma cleavage; Intracellular domain

Indexed keywords

ADAPTOR PROTEIN; AMYLOID PRECURSOR PROTEIN; CARBOXYL GROUP; GAMMA SECRETASE; GREEN FLUORESCENT PROTEIN; PROTEIN FE65; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS; COMPLEX FORMATION; CONTROLLED STUDY; CYTOPLASM; ENZYME RELEASE; FLUORESCENCE; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE MUTATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SENILE PLAQUE;

ACTIVE TRANSPORT, CELL NUCLEUS; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; CELL NUCLEUS; CYTOPLASM; ENDOPEPTIDASES; ENZYME INHIBITORS; GENES, REPORTER; GLIOMA; GREEN FLUORESCENT PROTEINS; HUMANS; LUMINESCENT PROTEINS; MACROMOLECULAR SUBSTANCES; MUTAGENESIS, SITE-DIRECTED; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SPECTROMETRY, FLUORESCENCE; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0036677928     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.01016.x     Document Type: Article

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