In silico discovery of β-secretase inhibitors

Journal of the American Chemical Society

Volumn 128, Issue 16, 2006, Pages 5436-5443

  Huang, Danzhi ^a   Lüthi, Urs ^b   Kolb, Peter ^a   Cecchini, Marco ^a   Barberis, Alcide ^b   Caflisch, Amedeo ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b ESBATech AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; DISEASES; FREE ENERGY; GENETIC ALGORITHMS; MOLECULAR WEIGHT; PROTEINS;

ENZYMATIC ASSAYS; INTERACTION ENERGY MODEL; MAMMALIAN CELLS; SOLVATION;

ENZYME INHIBITION;

ASPARTIC PROTEINASE; BETA SECRETASE; BETA SECRETASE INHIBITOR; TRIAZINE DERIVATIVE;

ARTICLE; DEMENTIA; DRUG ISOLATION; ELECTRICITY; ENERGY; ENZYME INHIBITION; GENETIC ALGORITHM; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC 50; PROTEIN CONFORMATION; PROTEIN DEGRADATION; SOLVATION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ELECTROCHEMISTRY; MODELS, MOLECULAR; PROTEASE INHIBITORS;

EID: 33646442795     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0573108     Document Type: Article

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