Release of a membrane-bound death domain by γ-secretase processing of the p75NTR homolog NRADD

Journal of Cell Science

Volumn 117, Issue 18, 2004, Pages 4099-4111

  Gowrishankar, Kavitha ^a   Zeidler, Michael G ^a   Vincenz, Claudius ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

secretase; Death domain; Metalloproteinases; NRADD; Presenilin

Indexed keywords

AMYLOID BETA PROTEIN; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; GLYCOPROTEIN; MEMBRANE PROTEIN; METALLOPROTEINASE; NEUROTROPHIN RECEPTOR ALIKE DEATH DOMAIN; PRESENILIN 1; PRESENILIN 2; PROTEIN P75; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; CELL DEATH; CELL NUCLEUS; CELL STRUCTURE; CELL TYPE; CONTROLLED STUDY; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MEMBRANE BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN SECRETION; SEQUENCE HOMOLOGY;

ACTIVE TRANSPORT, CELL NUCLEUS; ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; APOPTOSIS; ASPARTIC ENDOPEPTIDASES; CELL LINE; CELL MEMBRANE; CELL NUCLEUS; CHO CELLS; CRICETINAE; ENDOPEPTIDASES; ENZYME INHIBITORS; GLYCOSYLATION; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MICE; MOLECULAR WEIGHT; NIH 3T3 CELLS; ORGAN SPECIFICITY; PRESENILIN-2; PROTEIN ISOFORMS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, NERVE GROWTH FACTOR; RECEPTORS, DEATH DOMAIN; RECEPTORS, NERVE GROWTH FACTOR;

EID: 4944225803     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.01263     Document Type: Article

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