Transition-state analogue γ-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex

Biochemistry

Volumn 44, Issue 11, 2005, Pages 4332-4341

  Evin, Geneviève ^a   Canterford, Louise D ^a   Hoke, David E ^a   Sharples, Robyn A ^a   Culvenor, Janetta G ^a   Masters, Colin L ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ELECTROPHORESIS; GELS; GENES; IMMUNOLOGY; MEMBRANES; MODAL ANALYSIS; MOLECULAR WEIGHT; SIZE EXCLUSION CHROMATOGRAPHY;

AMYLOID PROTEINS; COMPLEXES; INHIBITORS; TRANSMEMBRANE DOMAINS;

ENZYMES;

3 [(3 CHOLAMIDOPROPYL)DIMETHYLAMMONIO] 2 HYDROXY 1 PROPANESULFONIC ACID; ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; BENZOPHENONE DERIVATIVE; BIOTIN DERIVATIVE; DIMETHYL SULFOXIDE; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; L 685458; NICASTRIN; PEPSTATIN; PRESENILIN 1; PRESENILIN 2; UNCLASSIFIED DRUG;

ARTICLE; CELL FRACTIONATION; DIMERIZATION; ENZYME INHIBITOR INTERACTION; ENZYME STABILITY; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; INHIBITION KINETICS; NEUROBLASTOMA CELL; PRIORITY JOURNAL;

AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; BINDING SITES; CARBAMATES; CELL LINE, TUMOR; CHROMATOGRAPHY, GEL; CROSS-LINKING REAGENTS; DETERGENTS; DIPEPTIDES; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOPEPTIDASES; ENZYME STABILITY; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MOLECULAR WEIGHT; MULTIPROTEIN COMPLEXES; PEPTIDE FRAGMENTS; PHOTOCHEMISTRY; PRESENILIN-1; PROTEASE INHIBITORS; PROTEIN BINDING; SOLUBILITY; SUBCELLULAR FRACTIONS;

EID: 15544380450     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0481702     Document Type: Article

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