Human aspartic protease memapsin 2 cleaves the β-secretase site of β-amyloid precursor protein

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 4, 2000, Pages 1456-1460

  Lin, Xinli ^a   Koelsch, Gerald ^a   Wu, Shili ^a   Downs, Debbie ^a   Dashti, Azar ^a   Tang, Jordan ^a,b  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Membrane aspartic proteases

Indexed keywords

AMYLOID PRECURSOR PROTEIN; ASPARTIC PROTEINASE; BETA SECRETASE; COMPLEMENTARY DNA; MESSENGER RNA; MUTANT PROTEIN; PRESENILIN 1; RECOMBINANT ENZYME;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; CYTOSOL; ENZYME KINETICS; ENZYME SPECIFICITY; HELA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROCESSING;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; BRAIN; CLONING, MOLECULAR; ENDOPEPTIDASES; ENZYME ACTIVATION; FLUORESCENT ANTIBODY TECHNIQUE; HELA CELLS; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; RECOMBINANT PROTEINS; RNA, MESSENGER; SEQUENCE ALIGNMENT; SUBSTRATE SPECIFICITY;

ESCHERICHIA COLI;

EID: 0034652309     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.4.1456     Document Type: Article

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