The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities

Journal of Biological Chemistry

Volumn 279, Issue 30, 2004, Pages 31329-31336

  Gu, Yongjun ^a   Sanjo, Nobuo ^a   Chen, Fusheng ^a   Hasegawa, Hiroshi ^a   Petit, Agnes ^a   Ruan, Xueying ^a   Li, Wenping ^a   Shier, Cortney ^a   Kawarai, Toshitaka ^a   Schmitt Ulms, Gerold ^a   Westaway, David ^a   St George Hyslop, Peter ^a,b   Fraser, Paul E ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b TORONTO WESTERN HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ASSOCIATION REACTIONS; BIOLOGICAL MEMBRANES; COMPLEXATION; MACROMOLECULES;

HETEROMERIC COMPLEXES; INTRAMEMBRANOUS PROTEOLYSIS; MACROMOLECULAR COMPLEXES; PRESENILIN PROTEINS;

PROTEINS;

AMYLOID PRECURSOR PROTEIN; ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; DETERGENT; GAMMA SECRETASE; MEMBRANE PROTEIN; NICASTRIN; NOTCH RECEPTOR; PRESENILIN 1; PRESENILIN 2; PROTEIN P75; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MACROMOLECULE; MEMBRANE BINDING; MOLECULAR WEIGHT; MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN STABILITY;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CELL LINE; CELLS, CULTURED; DETERGENTS; ENDOPEPTIDASES; HUMANS; MACROMOLECULAR SUBSTANCES; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MICE; MOLECULAR WEIGHT; MUTATION; NEUROGLIA; PRESENILIN-1; RECOMBINANT PROTEINS;

EID: 3843122101     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M401548200     Document Type: Article

References (29)

1. Sherrington, R., Rogaev, E., Liang, Y., Rogaeva, E., Levesque, G., Ikeda, M., Chi, H., Lin, C., Holman, K., Tsuda, T., Mar, L., Fraser, P., Rommens, J. M., and St George-Hyslop, P. (1995) Nature 375, 754-760
2. Rogaev, E. I., Sherrington, R., Rogaeva, E. A., Levesque, G., Ikeda, M., Liang, Y., Chi, H., Lin, C., Holman, K., Tsuda, T., Mar, L., Sorbi, S., Nacmias, B., Piacentini, S., Amaducci, L., Chumakov, I., Cohen, D., Lannfelt, L., Fraser, P. E., Rommens, J. M., and St George-Hyslop, P. (1995) Nature 376, 775-778
3. Levy-Lahad, E., Wijsman, E. M., Nemens, E., Anderson, L., Goddard, K. A., Weber, J. L., Bird, T. D., and Schellenberg, G. D. (1995) Science 269, 970-973
4. Goutte, C., Tsunozaki, M., Hale, V. A., and Priess, J. R. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 775-779
5. Francis, R., McGrath, G., Zhang, J., Ruddy, D. A., Sym, M., Apfeld, J., Nicoll, M., Maxwell, M., Hai, B., Ellis, M. C., Parks, A. L., Xu, W., Li, J., Gurney, M., Myers, R. L., Himes, C. S., Hiebsch, R., Ruble, C., Nye, J. S., and Curtis, D. (2002) Dev. Cell 3, 85-97
6. Yu, G., Nishimura, M., Arawaka, S., Levitan, D., Zhang, L., Tandon, A., Song, Y., Rogaeva, E., Chen, F., Kawarai, T., Supala, A., Levesque, L., Yu, H., Yang, D.-S., Holmes, E., Milman, P., Liang, Y., Zhang, D.-M., Xu, D.-H., X., Sato, C., Rogaev, E., Smith, M., Janus, C., Zhang, Y., Aebersold, R., Farrer, L., Sorbi, S., Bruni, A. C., Fraser, P. E., and St George-Hyslop, P. H. (2000) Nature 407, 48-54
7. Yu, G., Chen, F., Levesque, G., Nishimura, M., Zhang, D.-M., Levesque, L., Rogaeva, E., Xu, D., Liang, Y., Duthie, M., St George-Hyslop, P., and Fraser, P. E. (1998) J. Biol. Chem. 273, 16470-16475
8. Gu, Y., Chen, F., Sanjo, N., Kawarai, T., Hasegawa, H., Duthie, M., Li, W., Ruan, X., Luthra, A., Mount, H. T., Tandon, A., Fraser, P. E., and St George-Hyslop, P. (2003) J. Biol. Chem. 278, 7374-7380
9. LaVoie, M. J., Fraering, P. C., Ostaszewski, B. L., Ye, W., Kimberly, W. T., Wolfe, M. S., and Selkoe, D. J., (2003) J. Biol. Chem. 278, 37213-37222
10. Fraering, P. C., LaVoie, M. J., Ye, W., Ostaszewski, B. L., Kimberly, W. T., Selkoe, D. J., and Wolfe, M. S. (2004) Biochemistry 43, 323-333
11. Culvenor, J. G., Ilaya, N. T., Ryan, M. T., Canterford, L., Hoke, D. E., Williamson, N. A., McLean, C. A., Masters, C. L., and Evin, G. (2004) Eur. J. Biochem. 271, 375-385
12. Yang, D. S., Tandon, A., Chen, F., Yu, G., Yu, H., Arawaka, S., Hasegawa, H., Duthie, M., Schmidt, S. D., Ramabhadran, T. V., Nixon, R. A., Mathews, P. M., Gandy, S. E., Mount, H. T., St George-Hyslop, P., and Fraser, P. E. (2002) J. Biol. Chem. 277, 28135-28142
13. Chen, F., Yang, D.-S., Tandon, A., Rozmahel, R., Yu, G., Nishimura, M., Kawarai, T., Westaway, D., Gandy, S. E., Fraser, P. E., St George-Hyslop, P., and Fraser, P. E. (2000) J. Biol. Chem. 275, 36794-36802
14. Chen, F., Yu, G., Arawaka, S., Nishimura, M., Kawarai, T., Yu, H., Tandon, A., Supala, A., Song, Y., Rogaeva, E., Milman, P., Sato, C., Yu, C., Janus, C., Lee, J., Song, L., Zhang, L., Fraser, P., and St George-Hyslop, P. (2001) Nat. Cell Biol. 3, 751-754
15. Nishimura, M., Yu, G., Levesque, G., Zhang, D. M., Ruel, L., Chen, F., Milman, P., Holmes, E., Liang, Y., Kawarai, T., Jo, E., Supala, A., Rogaeva, E., Xu, D. M., Janus, C., Levesque, L., Bi, Q., Duthie, M., Rozmahel, R., Mattila, K., Lannfelt, L., Westaway, D., Mount, H. T., Woodgett, J., Fraser, P., and St George-Hyslop, P. (1999) Nat. Med. 5, 164-169
16. Chen, F., Gu, Y., Hasegawa, H., Ruan, X., Arawaka, S., Fraser, P., Westaway, D., Mount, H., and St George-Hyslop, P. (2002) J. Biol. Chem. 277, 36521-36526
17. Schagger, H., and von Jagow, G. (1991) Anal. Biochem. 199, 223-231
18. Li, Y.-M., Lai, M. T., Xu, M., Huang, Q., DiMuzio-Mower, J., Sardana, M. K., Shi, X.-P., Yin, K.-C., Shafer, J. A., and Gardell, S. J. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 6138-6143
19. Pinnix, I., Musunuru, U., Tun, H., Sridharan, A., Golde, T., Eckman, C., Ziani-Cherif, C., Onstead, L., and Sambamurti, K. (2001) J. Biol. Chem. 276, 481-487
20. Wolfe, M. S., Xia, W., Ostaszewski, B. L., Diehl, T. S., Kimberly, W. T., and Selkoe, D. S. (1999) Nature 398, 513-517
21. Steiner, H., Kostka, M., Romig, H., Basset, G., Pesold, B., Hardy, J., Capell, A., Meyn, L., Grim, M. L., Baumeister, R., Fechteler, K., and Haass, C. (2000) Nat. Cell Biol. 2, 848-851
22. Steiner, H., Duff, K., Capell, A., Romig, H., Grim, M. G., Lincoln, S., Hardy, J., Yu, X., Picciano, M., Fechteler, K., Citron, M., Kopan, R., Pesold, B., Keck, S., Baader, M., Tomita, T., Iwatsubo, T., Baumeister, R., and Haass, C. (1999) J. Biol. Chem. 274, 28669-28673
23. Yu, G., Chen, F., Nishimura, M., Steiner, H., Tandon, A., Kawarai, T., Arawaka, S., Supala, A., Song, Y.-Q., Rogaeva, E., Holmes, E., Zhang D-M., Milman, P., Fraser, P., Haass, C., and St George-Hyslop, P. (2000) J. Biol. Chem. 275, 27348-27353
24. Tian, G., Ghanekar, S. V., Aharony, D., Shenvi, A. B., Jacobs, R. T., Liu, X., and Greenberg, B. D. (2003) J. Biol. Chem. 278, 28968-28975
25. Hayashi, H., Mizuno, T., Michikawa, M., Haass, C., and Yanagisawa, K. (2000) Biochim. Biophys. Acta 1483, 81-90
26. Lee, S.-J., Liyanage, U., Bickel, P., Xia, W., Lansbury, P. T., and Kosik, K. (1998) Nat. Med. 4, 730-734
27. Haass, C., Koo, E. H., Mellon, A., Hung, A. Y., and Selkoe, D. J. (1992) Nature 357, 500-503
28. Koo, E. H., and Squazzo, S. L. (1994) J. Biol. Chem. 269, 17386-17389
29. Nixon, R. A., Mathews, P. M., and Cataldo, A. M. (2001) J. Alzheimers Dis. 3, 97-107