Rapid purification of active γ-secretase, an intramembrane protease implicated in Alzheimer's disease

Journal of Neurochemistry

Volumn 104, Issue 1, 2008, Pages 210-220

  Cacquevel, Matthias ^a   Aeschbach, Lorene ^a   Osenkowski, Pamela ^b   Li, Dongyang ^c   Ye, Wenjuan ^b   Wolfe, Michael S ^b   Li, Huilin ^c   Selkoe, Dennis J ^b   Fraering, Patrick C ^a  

^a EPFL   (Switzerland)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BROOKHAVEN NATIONAL LABORATORY   (United States)

Author keywords

Alzheimer's Disease; Amyloid; Gamma secretase; Intramembrane proteolysis

Indexed keywords

ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; GAMMA SECRETASE; MEMBRANE ENZYME; NICASTRIN; PRESENILIN 1; PRESENILIN 2; PROTEINASE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL LINE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; ELECTRON MICROSCOPY; ENZYME PURIFICATION; FEMALE; HUMAN; HUMAN CELL; IMAGE ANALYSIS; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; THREE DIMENSIONAL IMAGING; X RAY CRYSTALLOGRAPHY;

AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELL LINE, TRANSFORMED; CRICETINAE; CRICETULUS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MICROSCOPY, ELECTRON, TRANSMISSION;

MAMMALIA;

EID: 37249083548     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2007.05041.x     Document Type: Article

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