Functional overexpression of γ-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity

Journal of Biological Chemistry

Volumn 280, Issue 13, 2005, Pages 12523-12535

  Wrigley, Jonathan D J ^a   Schurov, Irina ^a   Nunn, Emma J ^a   Martin, Agnes C L ^a   Clarke, Earl E ^a   Ellis, Semantha ^a   Bonnert, Timothy P ^a   Shearman, Mark S ^a   Beher, Dirk ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CHROMATOGRAPHY; IMMUNOLOGY; POLYPEPTIDES; PROTEINS;

FUNCTIONAL OVEREXPRESSION; GOLGI COMPARTMENT; NICASTRIN;

LIPIDS;

AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; LIPID; POLYPEPTIDE; PROTEINASE;

ANTIBODY AFFINITY; ARTICLE; CATALYSIS; ENZYME ACTIVITY; GEL PERMEATION CHROMATOGRAPHY; GOLGI COMPLEX; HUMAN; HUMAN CELL; LIPID BRAIN LEVEL; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PURIFICATION; SOLUBILIZATION; STOICHIOMETRY;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; BINDING SITES; BLOTTING, WESTERN; BRAIN; CATALYSIS; CELL LINE; CELL MEMBRANE; CELL-FREE SYSTEM; CHROMATOGRAPHY; CULTURE MEDIA; CULTURE MEDIA, CONDITIONED; DIMERIZATION; DNA, COMPLEMENTARY; ENDOPEPTIDASES; GOLGI APPARATUS; HUMANS; IMMUNOHISTOCHEMISTRY; LIPID METABOLISM; MEMBRANE GLYCOPROTEINS; PEPTIDE HYDROLASES; PEPTIDES; PROTEIN STRUCTURE, TERTIARY; TIME FACTORS;

EID: 16844367458     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M413086200     Document Type: Article

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