The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "γ-secretase" cleavage

Journal of Biological Chemistry

Volumn 278, Issue 10, 2003, Pages 7751-7754

  Ikeuchi, Takeshi ^b   Sisodia, Sangram S ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DISEASES; MUTAGENESIS; SIGNALING;

MOLECULAR INTERACTIONS;

BIOCHEMISTRY;

GAMMA SECRETASE; LUCIFERASE; NOTCH RECEPTOR; PRESENILIN 1; PROTEIN DELTA1; PROTEIN JAGGED2; UNCLASSIFIED DRUG; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; BACE1 PROTEIN, MOUSE; CARRIER PROTEIN; JAG2 PROTEIN, HUMAN; JAG2 PROTEIN, MOUSE; LIGAND; MEMBRANE PROTEIN; PRIMER DNA; PROTEIN; PROTEINASE; PSEN1 PROTEIN, HUMAN; SECRETASE; SIGNAL PEPTIDE;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CELL FATE; CHIMERA; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROCESSING; REPORTER GENE; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; HYDROLYSIS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; SEQUENCE HOMOLOGY;

ANIMALIA;

AMINO ACID SEQUENCE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BASE SEQUENCE; CARRIER PROTEINS; CELL LINE; DNA PRIMERS; ENDOPEPTIDASES; HUMANS; HYDROLYSIS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; PRESENILIN-1; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0037424348     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C200711200     Document Type: Article

References (29)

1. Price, D. L., Tanzi, R. E., Borchelt, D. R., and Sisodia, S. S. (1998) Annu. Rev. Genet. 32, 461-493
2. De Strooper, B., Satig, P., Craessaerts, K., Vanderstichele, H., Guhde, G., Annaert, W., Von Figura, K., and Van Leuven, F. (1998) Nature 391, 387-390
3. Naruse, S., Thinakaran, G., Luo, J. J., Kusiak, J. W., Tomita, T., Iwstsubo, T., Qian, X., Ginty, D. D., Price, D. L., Borchelt, D. R., Wong, P. C., and Sisodia, S. S. (1998) Neuron 21, 1213-1221
4. De Strooper, B., Annaertm, W., Cuper, P., Saftig, P., Craessaerts, K., Mumm, J. S., Schroeter, E. H., Schrijver, V., Wolfe, M. S., Ray, W. J., Goate, A., and Kopan, R. (1999) Nature 398, 518-522
5. Struhl, G., and Greenwald, I. (1999) Nature 398, 522-525
6. Ni, C.-Y., Murphy, M. P., Golde, T. E., and Carpenter, G. (2000) Science 294, 2179-2181
7. Marambaud, P., Shioi, J., Serban, G., Georgakopoulos, A., Sarner, S., Nagy, V., Biki, L., Wen, P., Efthimiopoulos, S., Shao, Z., Wisniewski, T., and Robakis, N. K. (2002) EMBO J. 21, 1948-1956
8. May, P., Reddy, Y. K., and Herz, J. (2002) J. Biol. Chem. 277, 18736-18743
9. Lammich, S., Okochi, M., Takeda, M., Kaether, C., Capell, A., Zimmer, A.-K., Edbauer, D., Walter, J., Steiner, H., and Haass, C. (2002) J. Biol. Chem. 277, 44754-44759
10. Kim, D. Y., MacKenzie Ingano, L. A., and Kovacs, D. M. (2002) J. Biol. Chem. 277, 49976-49981
11. Artavanis-Tsakonas, S., Rand, M. D., and Lake, R. J. (1999) Science 284, 770-776
12. Logeat, F., Bessia, C., Brou, C., LeBail, O., Jarriault, S., Seiday, N., and Israel, A. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 8108-8112
13. Blaumueller, C. M., Qi, H., Zagoukas, P., and Artavanis-Tsakonas, S. (1997) Cell 90, 281-291
14. Brou, C., Logeat, F., Gupta, N., Bessia, C., LeBail, O., Doedens, J. R., Cumano, A., Roux, P., Black, R. A., and Israel, A. (2000) Mol. Cell 5, 207-216
15. Mumm, J. S., Schroeter, E. H., Saxena, M. T., Griesemer, A., Tian, X., Pan, D. J., Ray, W. J., and Kopan, R. (2000) Mol. Cell 5, 197-206
16. Schroeter, E. H., Kisslinger, J. A., and Kopan, R. (1998) Nature 393, 382-386
17. Struhl, G., and Adachi, A. (1998) Cell 93, 649-660
18. Grace, G. E., Mann, R. S., Mitsiadis, E., Henrique, D., Carcangiu, M.-L., Banks, A., Leiman, J., Ward, D., Ish-Horowitz, D., and Artavanis-Tsakonas, A. (1999) Am. J. Pathol. 165, 785-794
19. Lindsell, C. E., Shawber, C. J., Boulter, J., and Weinmaster, G. (1995) Cell 80, 909-917
20. Qi, H., Rand, M. D., Wu, X., Sestan, N., Wang, W., Rakic, P., Xu, T., and Artavanis-Tsakonas, S. (1999) Science 283, 91-94
21. Mishra-Gorur, K., Rand, M. D., Perez-Villamil, B., and Artavanis-Tsakonas, S. (2002) J. Cell Biol. 159, 313-324
22. Shearman, M. S., Beher, D., Clark, E. E., Lewis, H. D., Harrison, T., Hunt, P., Nadin, A., Smith, A. L., Stevenson, G., and Castro, J. L. (2000) Biochemistry 39, 8698-8704
23. Thinakaran, G., Harris, C. L., Ratovitski, T., Davenport, F., Slunt, H. H., Price, D. L., Borchelt, D. R., and Sisodia, S. S. (1997) J. Biol. Chem. 272, 28415-28422
24. Kim, S.-H., Leem, J. Y., Lah, J. J., Slunt, H. H., Levey, A. I., Thinakaran, G., and Sisodia, S. S. (2001) J. Biol. Chem. 276, 43343-43350
25. Thinakaran, G., Getard, F. B., Bouton, C. M. L., Harris, C. L., Price, D. L., Borchelt, D. R., and Sisodia, S. S. (1998) Neurobiol. Dis. 4, 438-453
26. Cao, X., and Südhof, T. (2001) Science 293, 115-120
27. Moehlmann, T., Winkler, E., Xia, X., Edbauer, D., Murrell, J., Capell, A., Kaether, C., Zheng, H., Ghetti, B., Haass, C., and Steiner, H. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 8025-8030
28. Chen, F., Gu, Y. J., Hasegawa, H., Ruan, X., Arawaka, S., Fraser, P., Westaway, D., Mount, H., and St. George-Hyslop, P. (2002) J. Biol. Chem. 277, 36521-36526
29. Song, W., Nadeau, P., Yuan, M., Yang, X., Shen, J., and Yankner, B. A. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 6959-6963