Difluoro ketone peptidomimetics suggest a large S1 pocket for Alzheimer's γ-secretase: Implications for inhibitor design

Journal of Medicinal Chemistry

Volumn 43, Issue 18, 2000, Pages 3434-3442

  Moore, C L ^a   Leatherwood, D D ^a   Diehl, T S ^b   Selkoe, D J ^b   Wolfe, M S ^a,b  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

[4 [[(N TERT BUTOXYCARBONYL)VALYL]AMINO 2,2 DIFLUORO 5 CYCLOHEXYL 3 OXOHEXANOYL]VALYL]ISOLEUCINE METHYL ESTER; ALCOHOL DERIVATIVE; AMYLOID BETA PROTEIN; ASPARTIC PROTEINASE; ENZYME INHIBITOR; FLUORINE DERIVATIVE; GAMMA SECRETASE; KETONE DERIVATIVE; PRESENILIN 1; PRESENILIN 2; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME SPECIFICITY; GENETIC TRANSFECTION; MOLECULAR MIMICRY; NONHUMAN; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; STEREOSPECIFICITY;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CATALYTIC DOMAIN; CELL LINE; CHO CELLS; CRICETINAE; DRUG DESIGN; ENDOPEPTIDASES; KETONES; MOLECULAR MIMICRY; PEPTIDE FRAGMENTS; PEPTIDES; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034618705     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000100f     Document Type: Article

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