A presenilin-1/γ-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

EMBO Journal

Volumn 21, Issue 8, 2002, Pages 1948-1956

  Marambaud, Philippe ^a   Shioi, Junichi ^a   Serban, Geo ^a   Georgakopoulos, Anastasios ^b   Sarner, Shula ^c   Nagy, Vanja ^d   Baki, Lia ^e   Wen, Paul ^e   Efthimiopoulos, Spiros ^f   Shao, Zhiping ^f   Wisniewski, Thomas ^f   Robakis, Nikolaos K ^f  

^a DIVISION OF REPRODUCTIVE BIOLOGY   (United States)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c RESEARCH AND DEVELOPMENT   (Australia)

^d College of Chemistry and Molecular Engineering ^*  (China)

^e UNIVERSITY OF SHEFFIELD   (United Kingdom)

^f MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; E cadherin; Presenilin 1; catenin; secretase

Indexed keywords

BETA CATENIN; PRESENILIN 1; UVOMORULIN;

ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL ADHESION; CELL DIFFERENTIATION; CELL JUNCTION; CYTOSKELETON; ENZYME REGULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN PROCESSING; TISSUE GROWTH; TRANSCRIPTION REGULATION;

ADHERENS JUNCTIONS; AMINO ACID SEQUENCE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BINDING SITES; CADHERINS; ENDOPEPTIDASES; HUMANS; INTRACELLULAR FLUID; MATRIX METALLOPROTEINASES; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; PRESENILIN-1; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 18344380083     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/21.8.1948     Document Type: Article

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