The First Proline of PALP Motif at the C Terminus of Presenilins is Obligatory for Stabilization, Complex Formation, and γ-Secretase Activities of Presenilins

Journal of Biological Chemistry

Volumn 276, Issue 35, 2001, Pages 33273-33281

  Tomita, Taisuke ^a   Watabiki, Tomonari ^a   Takikawa, Rie ^a   Morohashi, Yuichi ^a   Takasugi, Nobumasa ^a   Kopan, Raphael ^b   De Strooper, Bart ^c   Iwatsubo, Takeshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b WASHINGTON UNIVERSITY   (United States)

^c DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CELLS; DISEASES; ENZYMES; GENES; MOLECULAR WEIGHT;

MULTIPASS TRANSMEMBRANE PROTEINS;

BIOCHEMISTRY;

ALANINE; AMYLOID BETA PROTEIN; GAMMA SECRETASE; GENE PRODUCT; LEUCINE; MEMBRANE PROTEIN; MUTANT PROTEIN; NOTCH RECEPTOR; PRESENILIN; PROLINE; UNCLASSIFIED DRUG; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; BACE1 PROTEIN, MOUSE; PRESENILIN 1; PRESENILIN 2; PROTEINASE; PSEN1 PROTEIN, HUMAN; PSEN2 PROTEIN, HUMAN; RECOMBINANT PROTEIN; SECRETASE;

ALZHEIMER DISEASE; AMINO ACID COMPOSITION; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CAENORHABDITIS ELEGANS; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; DROSOPHILA MELANOGASTER; ENZYME ACTIVITY; FAMILIAL DISEASE; GENE MUTATION; GENETIC CONSERVATION; GOLGI COMPLEX; MISSENSE MUTATION; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MOTIF; PROTEIN STABILITY; PROTEIN STRUCTURE; TRANS GOLGI NETWORK; AMINO ACID SEQUENCE; ANIMAL; CAENORHABDITIS; CATTLE; CELL LINE; CHEMISTRY; GENETIC TRANSFECTION; GENETICS; HUMAN; KINETICS; METABOLISM; MOLECULAR GENETICS; RAT; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY;

ANIMALIA; CAENORHABDITIS; CAENORHABDITIS ELEGANS; DROSOPHILA MELANOGASTER; MELANOGASTER;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CAENORHABDITIS; CATTLE; CELL LINE; DROSOPHILA MELANOGASTER; ENDOPEPTIDASES; HUMANS; KINETICS; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; PRESENILIN-1; PRESENILIN-2; PROLINE; RATS; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; TRANSFECTION;

EID: 0035980073     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M011152200     Document Type: Article

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