Therapeutic benefits from targeting of ADAM family members

Biochemistry

Volumn 43, Issue 23, 2004, Pages 7227-7235

  Moss, Marcia L ^a   Bartsch, Jörg W ^b  

^a BioZyme Inc   (United States)

^b BIELEFELD UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CELLS; DISEASES; ENZYMES; PHYSIOLOGY;

GROWTH FACTORS; PHYSIOLOGICAL PROCESSES;

BIOMEDICAL ENGINEERING;

ADAM 10; ADAM 19; ADAM 8; ADAM PROTEIN; CELL SURFACE RECEPTOR; CYTOKINE; DISINTEGRIN; GROWTH FACTOR; MEMBRANE PROTEIN; METALLOPROTEINASE; PROTEINASE; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; UNCLASSIFIED DRUG;

ENZYME ACTIVITY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; DISINTEGRINS; DRUG DESIGN; GROWTH SUBSTANCES; HUMANS; INFLAMMATION; MEMBRANE PROTEINS; METALLOPROTEASES;

EID: 2942567828     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi049677f     Document Type: Review

References (84)

1. Hooper, N. M., Karran, E. H., and Turner, A. J. (1997) Membrane protein secretases, Biochem. J. 321, 265-279.
2. Wolfsberg, T. G., Straight, P. D., Gerena, R. L., Huovila, A. P., Primakoff, P., Myles, D. G., and White, J. M. (1995) ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and metalloprotease domain, Dev. Biol. 69, 378-383.
3. Black, R. A., Rauch, C. T., Kozlosky, C. J., Peschon, J. J., Slack, J. L., Wolfson, M. F., Castner, B. J., Stocking, K. L., Reddy, P., Srinivasan, S., Nelson, N., Bolani, N., Schooley, K. A., Gerhart, M., Davis, R., Fitzner, J. N., Johnson, R. S., Paxton, R. J., March, C. J., and Cerretti, D. P. (1997) A Metalloproteinase Disintegrin That Releases Tumor-Necrosis Factor-α From Cells, Nature 385, 729-733.
4. Moss, M. L., Jin, S.-L. C., Milla, M. E., Burkhart, W., Carter, H. L., Chen, W.-J., Clay, W. C., Didsbury, J. R., Hassler, D., Hoffman, C. R., Kost, T. A., Lambert, M. H., Leesnitzer, M. A., McCauley, P., McGeehan, G., Mitchell, J., Moyer, M., Pahel, G., Rocque, W., Overton, L. K., Schoenen, F., Seaton, T., Su, J.-L., Warner, J., Willard, D., and Becherer, J. D. (1997) Cloning of a Disintegrin Metalloprotease That Processes Tumor-Necrosis Factor-α, Nature 385, 733-736.
5. Peschon, J. J., Slack, J. L., Reddy, P., Stocking, K. L., Sunnarborg, S. W., Lee, D. C., Russell, W. E., Castner, B. J., Johnson, R. S., Fitzner, J. N., Boyce, R. W., Nelson, N., Kozlosky, C. J., Wolfson, M. F., Rauch, C. T., Cerretti, D. P., Paxton, R. J., March, C. J., and Black, R. A. (1998) An Essential Role for Ectodomain Shedding in Mammalian Development, Science 282, 1281-1284.
6. Hinkle, C. L., Mohan, M. J., Lin, P., Yeung, N., Rasmussen, F., Milla, M. E., and Moss, M. L. (2003) Multiple Metalloproteinases Process ProTransforming Growth Factor-α (ProTGF-α), Biochemistry 42, 2127-2136.
7. Sunnarborg, S. W., Hinkle, C. L., Stevenson, M., Russell, W. E., Raska, C. S., Peschon, J. J., Castner, B. J., Gerhart, M. J., Paxton, R. J., Black, R. A., and Lee, D. C. (2002) Tumor Necrosis Factor-α Converting Enzyme (TACE) Regulates Epidermal Growth Factor Receptor Ligand Availability, J. Biol. Chem. 277, 12838-12845.
8. Asakura, M., Kitakaze, M., Takashima, S., Liao, Y., Ishikura, F., Yoshinaka, T., Ohmoto, H., Node, K., Yoshino, K., Ishiguro, H., Asanuma, H., Sanada, S., Matsumura, Y., Takeda, H., Beppu, S., Tada, M., Hori, M., and Higashiyama, S. (2002) Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: Metalloproteinase inhibitors as a new therapy, Nat. Med. 8, 35-40.
9. Lemjabbar, H., and Basbaum, C. (2002) Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureas in epithelial cells, Nat. Med. 8, 41-46.
10. Yan, Y., Shirakabe, K., and Werb, Z. (2002) The metalloproteinase Kuzbanian (ADAM 10) mediates the transactivation of EGF receptor by G protein-coupled receptors, J. Cell Biol. 158, 221-226.
11. Gschwind, A., Hart, S., Fischer, O. M., and Ullrich, A. (2003) A TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells, EMBO J. 22, 2411-2421.
12. Buxbaum, J. D., Liu, K. N., Luo, Y., Slack, J. L., Stocking, K. L., Peschon, J. J., Johnson, R. S., Castner, B. J., Cerretti, D. P., and Black, R. A. (1998) Evidence that tumor necrosis factor α converting enzyme is involved in regulated α-secretase cleavage of the Alzheimer amyloid protein precursor, J. Biol. Chem. 273, 27765-27767.
13. Lammich, S., Kojro, E., Postina, R., Gilbert, S., Pfeiffer, R., Jasionowski, M., Haass, C., and Fahrenholz, F. (1999) Constitutive and regulated α-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease, Proc. Natl. Acad. Sci. U.S.A. 96, 3922-3927.
14. Brou, C., Lofeat, F., Gupta, N., Bessia, C., LeBail, O., Doedens, J. R., Cumano, A., Roux, P., Black, R. A., and Israel, A. (2000) A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE, Mol. Cell 5, 207-216.
15. Hartmann, D., deStrooper, B., Serneels, L., Craessaerts, K., Herreman, A., Annaert, W., Umans, L., Lubke, T., Lena Illert, A., von Figura, K., and Saftig, P. (2002) The disintegrin/ metalloprotease ADAM 10 is essential for Notch signalling but not for α-secretase activity in fibroblasts, Hum. Mol. Genet. 11, 2615-2624.
16. Mullberg, J., Durie, F. H., Otten-Evans, C., Alderson, M. R., Rose-John, S., Cosman, D., Black, R. A., and Mohler, K. M. (1995) A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNF receptor, J. Immunol. 155, 5198-5205.
17. Reddy, P., Slack, J. L., Davis, R., Cerretti, D. P., Kozlosky, C. J., Blanton, R. A., Shows, D., Peschon, J. J., and Black, R. A. (2000) Functional analysis of the domain structure of tumor necrosis factor-α converting enzyme, J. Biol. Chem. 275, 14608-14614.
18. Hintz, K. A., Rassias, A. J., Wardwell, K., Moss, M. L., Morganelli, P. M., Pioli, P. A., Givan, A. L., Wallace, P. K., Yeager, M. P., and Guyre P. M. (2002) Endotoxin induces rapid metalloproteinase-mediated shedding followed by upregulation of the monocyte hemoglobin scavenger receptor CD163, J. Leukocyte Biol. 72, 711-717.
19. Zhang, Y., Jiang, J., Black, R. A., Baumann, G., and Frank, S. J. (2000) Tumor necrosis factor-α converting enzyme (TACE) is a growth hormone binding protein (GHBP) sheddase: the metalloprotease TACE/ADAM-17 is critical for (PMA-induced) GH receptor proteolysis and GHBP generation, Endocrinology 141, 4342-4348.
20. Mechtersheimer, S., Gutwein, P., Agmon-Levin, N., Stoeck, A., Oleszewski, M., Riedle, S., Postina, R., Fahrenholz, F., Fogel, M., Lemmon, V., and Altevogt, P. (2001) Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins, J. Cell Biol. 155, 661-673.
21. Naus, S., Richter, M., Wildeboer, D., Schachner, M., Moss, M., and Bartsch, J. W. (2004) Ectodomain shedding of the neural recognition molecule CHL1 by the metalloprotease-disintegrin ADAM8 promotes neurite outgrowth and suppresses neuronal cell death, J. Biol. Chem. (in press).
22. Mohan, M. J., Seaton, T., Mitchell, J., Howe, A., Blackburn, K., Burkhart, W., Moyer, M., Patel, I., Waitt, G. M., Becherer, J. D., Moss, M. L., and Milla, M. E. (2002) The tumor necrosis factor-α converting enzyme (TACE): a unique metalloproteinase with highly defined substrate selectivity, Biochemistry 41, 9462-9469.
23. Rovida, E., Paccagnini, A., Del Rosso, M., Peschon, J. J., and Dello Sbarba, P. (2001) TNF-α-converting enzyme cleaves the macrophage colony-stimulating factor receptor in macrophages undergoing activation, J. Immunol. 166, 1583-1589.
24. Fourie, A. M., Coles, F., Moreno, V., and Karlsson, L. (2003) Catalytic activity of ADAM8, ADAM15 and MDC-L (ADAM28) on synthetic peptide substrates, and in ectodomain cleavage of CD23, J. Biol. Chem. 278, 30469-30477.
25. Rio, C., Buxbaum, J. D., Peschon, J. J., and Corfas, G. (2000) Tumor necrosis factor-α-converting enzyme is required for cleavage of erbB4/HER4, J. Biol. Chem. 275, 10379-10387.
26. Shirakabe, K., Wakatsuki, S., Kurisaki, T., and Fujisawa-Sehara, A. (2001) Roles of Meltrin β/ADAM19 in the processing of neuregulin, J. Biol. Chem. 276, 9352-9358.
27. Moss, M. L., et al. (1999) TNF Convertase, in Metalloproteinases as Targets for Anti-inflammatory Drugs (Bradshaw, D., Nixon, J. S., and Bottemley, K., Eds.) Birkhauser, Boston.
28. Rosendahl, M. S., Ko, S. C., Long, D. L., Brewer, M. T., Rosenzweig, B., Hedl, E., Anderson, L., Pyle, S. M., Moreland, J., Meyers, M. A., Kohno, T., Lyons, D., and Lichenstein, H. S. (1997) Identification and characterization of a pro-tumor necrosis factor-α-processing enzyme from the ADAM family of zinc metalloproteases, J. Biol. Chem. 272, 24588-24593.
29. Lunn, C. A., Fan, X., Dalie, B., Miller, K., Zavodny, P. J., Narula, S. K., and Lundell, D. (1997) Purification of ADAM 10 from bovine spleen as a TNF α convertase, FEBS Lett. 400, 333-335.
30. Luetteke, N. C., Qiu, T. H., Peiffer, R. L., Oliver, P., Smithies, O., and Lee, D. C. (1993) TGF α deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice, Cell 73, 263-278.
31. Mann, G. B., Fowler, K. J., Gabriel, A., Nice, E. C., Williams, R. L., and Dunn, A. R. (1993) Mice with a null mutation of the TGF-α gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation, Cell 73, 249-261.
32. Miettinen, P. J., Berger, J. E., Meneses, J., Phung, Y., Pedersen, R. A., Werb, Z., and Derynck, R. (1995) Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor, Nature 376, 337-341.
33. Threadgill, D. W., Dlugosz, A. A., Hansen, L. A., Tennenbaum, T., Lichti, U., Yee, D., LaMantia, C., Mourton, T., Herrup, K., and Harris, R. C. (1995) Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype, Science 269, 230-234.
34. Sibilia, M., and Wagner, E. F. (1995) Strain-dependent epithelial defects in mice lacking the EGF receptor, Science 269, 234-238.
35. Jackson, L. F., Qiu, T. H., Sunnarborg, S. W., Chang, A., Zhang, C., Patterson, C., and Lee, D. C. (2003) Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling, EMBO J. 22, 2704-2716.
36. Iwamoto, R., Yamazaki, S., Asakura, M., Takashima, S., Hasuwa, H., Miyado, K., Adachi, S., Kitakaze, M., Hashimoto, K., Raab, G., Nanba, D., Higashiyama, S., Hori, M., Klagsbrun, M., and Mekada, E. (2003) Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function, Proc. Natl. Acad. Sci. U.S.A. 100, 3221-3226.
37. Arribas, J., Coodly, L., Vollmer, P., Kishimoto, T. K., Rose-John, S., and Massague, J. (1996) Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprotease inhibitors, J. Biol. Chem. 271, 11376-11382.
38. Borroto, A., Ruiz-Paz, S., de la Torre, T. V., Borrell-Pages, M., Merlos-Suarez, A., Pandiella, A., Blobel, C. P., Baselga, J., and Arribas J. (2003) Impaired trafficking and activation of tumor necrosis factor-α-converting enzyme in cell mutants defective in protein ectodomain shedding, J. Biol. Chem. 278, 25933-25939.
39. Allinson, T. M., Parkin, E. T., Turner, A. J., and Hooper, N. M. (2003) ADAMs family members as amyloid precursor protein α-secretases, J. Neurosci. Res. 74, 342-352.
40. Tandon, A., and Fraser, P. (2002) The presenilins. Gen. Biol. 3, 3014.
41. Asai, M., Hattori, C., Szabo, B., Sasagawa, N., Maruyama, K., Tanuma, S., and Ishiura, S. (2003) Putative function of ADAM9, ADAM10, and ADAM17 as APP α-secretase, Biochem. Biophys. Res. Commun. 301, 231-235.
42. Rooke, J., Pan, D., Xu, T., and Rubin, G. M. (1995) KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis, Science 273, 1227-1231.
43. Wen, C., Metzstein, M. M., and Greenwald, I. (1997) SUP-17, a Caenorhabditis elegans ADAM protein related to Drosophila KUZBANIAN, and its role in LIN-12/NOTCH signalling, Development 124, 4759-4767.
44. Prenzel, N., Zwick, E., Daub, H., Leserer, M., Abraham, R., Wallasch, C., and Ullrich, A. (1999) EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF, Nature 402, 884-888.
45. Amaoutova, I., Smith, A. M., Coates, L. C., Sharpe, J. C., Dhanvantari, S., Snell, C. R., Birch, N. P., and Loh, Y. P. (2003) The prohormone processing enzyme PC3 is a lipid raft-associated transmembrane protein, Biochemistry 42, 10445-10455.
46. von Tresckow, B., Kallen, K. J., von Strandmann, E. P., Borchmann, P., Lange, H., Engert, A., and Hansen, H. P. (2004) Depletion of cellular cholesterol and lipid rafts increases shedding of CD30, J. Immunol. 172, 4324-4331.
47. Kojro, E., Gimpl, G., Lammich, S., Marz, W., and Fahrenholz, F. (2001) Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM10, Proc. Natl. Acad. Sci. U.S.A. 98, 5815-5820.
48. Ehehalt, R., Keller, P., Haass, C., Thiele, C., and Simons, K. (2003) Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts, J. Cell Biol. 160, 113-123.
49. Gutwein, P., Mechtersheimer, S., Riedle, S., Stoeck, A., Gast, D., Joumaa, S., Zentgraf, H., Fogel, M., and Altevogt, D. P. (2003) ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles, FASEB J. 17, 292-294.
50. Wakatsuki, S., Kurisaki, T., and Sehara-Fujisawa, A. (2004) Lipid rafts identified as locations of ectodomain shedding mediated by Meltrin β/ADAM19, J. Neurochem. 89, 119-123.
51. Maecker, H. T., Todd, S. C., and Levy, S. (1997) The tetraspanin superfamily: molecular facilitators, FASEB J. 11, 428-442.
52. 1 at the cell-cell contact sites, J. Cell Biol. 129, 1691-1705.
53. 1 integrins, J. Biol. Chem. 276, 25005-25013.
54. 1 integrin, J. Biol. Chem. 278, 208-218.
55. 1 physically and functionally associate with CD36 in human melanoma cells. Requirement for the extracellular domain OF CD36, J. Biol. Chem. 275, 35264-35275.
56. Hundhausen, C., Misztela, D., Berkhout, T. A., Broadway, N., Saftig, P., Reiss, K., Hartmann, D., Fahrenholz, F., Postina, R., Matthews, V., Kallen, K. J., Rose-John, S., and Ludwig, A. (2003) The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion, Blood 102, 1186-1195.
57. Chesneau, V., Becherer, J. D., Zheng, Y., Erdjument-Bromage, H., Tempst, P., and Blobel, C. P. (2003) Catalytic properties of ADAM19, J. Biol. Chem. 278, 22331-22340.
58. Yoshiyama, K., Higuchi, Y., Kataoka, M., Matsuura, K., and Yamamoto, S. (1997) CD156 (human ADAM8): expression, primary amino acid sequence, and gene location, Genomics 41, 56-62.
59. Schlomann, U., Rathke-Hartlieb, S., Yamamoto, S., Jockusch, H., and Bartsch, J. W. (2000) Tumor necrosis factor α induces a metalloprotease-disintegrin, ADAM8 (CD 156): implications for neuron-glia interactions during neurodegeneration, J. Neurosci. 20, 7964-7971.
60. Schlomann, U., Wildeboer, D., Webster, A., Antropova, O., Zeuschner, D., Knight, C. G., Docherty, A. J., Lambert, M., Skelton, L., Jockusch, H., and Bartsch, J. W. (2002) The metalloprotease disintegrin ADAM8. Processing by autocatalysis is required for proteolytic activity and cell adhesion, J. Biol. Chem. 277, 48210-48219.
61. Amour, A., Knight, C. G., English, W. R., Webster, A., Slocombe, P. M., Knauper, V., Docherty, A. J. P., Becherer, J. D., Blobel, C. P., and Murphy G. (2002) The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs, FEBS Lett. 524, 154-158.
62. Delespesse, G., Sarfati, M., Wu, C. Y., Fournier, S., and Letellier, M. (1992) The low-affinity receptor for IgE, Immunol. Rev. 125, 77-97.
63. Higuchi, Y., Yasui, A., Matsuura, K., and Yamamoto, S. (2002) CD156 transgenic mice. Different responses between inflammatory types, Pathobiology 70, 47-54.
64. Loechel, F., Fox, J. W., Murphy, G., Albrechtsen, R., and Wewer, U. M. (2000) ADAM 12-S cleaves IGFBP-3 and IGFBP-5 and is inhibited by TIMP-3, Biochem. Biophys. Res. Commun. 278, 511-515.
65. Kawaguchi, N., Xu, X., Tajima, R., Kronqvist, P., Sundberg, C., Loechel, F., Albrechtsen, R., and Wewer, U. M. (2002) ADAM 12 protease induces adipogenesis in transgenic mice, Am. J. Pathol. 160, 1895-1903.
66. Kurisaki, T., Masuda, A., Sudo, K., Sakagami, J., Higashiyama, S., Matsuda, Y., Nagabukuro, A., Tsuji, A., Nabeshima, Y., Asano, M., Iwakura, Y., and Sehara-Fujisawa, A. (2003) Phenotypic analysis of Meltrin α (ADAM12)-deficient mice: involvement of Meltrin α in adipogenesis and myogenesis, Mol. Cell. Biol. 23, 55-61.
67. Van Eerdewegh, P., Little, R. D., Dupuis, J., Del Mastro, R. G., Falls, K., Simon, J., Torrey, D., Pandit, S., McKenny, J., Braunschweiger, K., Walsh, A., Liu, Z., Hayward, B., Folz, C., Manning, S. P., Bawa, A., Saracino, L., Thackston, M., Benchekroun, Y., Capparell, N., Wang, M., Adair, R., Feng, Y., Dubois, J., FitzGerald, M. G., Huang, H., Gibson, R., Allen, K. M., Pedan, A., Danzig, M. R., Umland, S. P., Egan, R. W., Cuss, F. M., Rorke, S., Clough, J. B., Holloway, J. W., Holgate, S. T., and Keith, T. P. (2002) Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness, Nature 418, 426-430.
68. Zou, J., Zhu, F., Liu, J., Wang, W., Zhang, R., Garlisi, C. G., Liu, Y., Wang, S., Shah, H., Wan, Y., and Umland, S. P. (2003) Catalytic activity of human ADAM33 (A disintegrin and metalloproteinase), J. Biol. Chem. (in press).
69. Friedlander, D. H. (1979) Captopril and propranolol in mild and moderate essential hypertension: preliminary report, N. Z. Med. J. 90, 146-149.
70. Drummond, A. H., Beckett, P., Brown, P. D., Bone, E. A., Davidson, A. H., Galloway, W. A., Gearing, A. J., Huxley, P., Laber, D., McCourt, M., Whittaker, M., Wood, L. M., and Wright, A. (1999) Preclinical and clinical studies of MMP inhibitors in cancer, Ann. N.Y. Acad. Sci. 878, 228-235.
71. Close, D. R. (2001) Matrix metalloproteinase inhibitors in rheumatic diseases, Ann. Rheum. Dis. 60 (Suppl. 3), 62-67.
72. Brown, P. D. (1999) Clinical studies with matrix metalloproteinase inhibitors in cancer therapy, APMIS 107, 174-180.
73. Holmbeck, K., Bianco, P., Caterina, J., Yamada, S., Kromer, M., Kuznetsov, S. A., Mankani, M., Robey, P. G., Poole, A. R., Pidoux, I., Ward, J. M., and Birkedal-Hansen, H. (1999) MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover, Cell 99, 81-92.
74. Corry, D. B., Rishi, K., Kanellis, J., Kiss, A., Song, L., Xu, J., Feng, L., Werb, Z., and Kheradmand, F. (2002) Decreased allergic lung inflammatory cell egression and increased susceptibility to asphyxiation in MMP2-defiency, Nat. Immunol. 3, 347-353.
75. Borrell-Pages, M., Rojo, F., Albanell, J., Baselga, J., and Arribas, J. (2003) TACE is Required for the Activation of the EGFR by TGF-α in Tumors, EMBO J. 22, 1114-1124.
76. De Luca, A., Arra, C., D'Antonio, A., Casamassimi, A., Losito, S., Ferraro, P., Ciardiello, F., Salomon, D. S., and Normanno, N. (2000) Simultaneous blockage of different EGF-like growth factors results in efficient growth inhibition of human colon carcinoma xenografts, Oncogene 19, 5863-5871.
77. Karashima, T., Sweeney, P., Slaton, J. W., Kim, S. J., Kedar, D., Izawa, J. I., Fan, Z., Pettaway, C., Hicklin, D. J., Shuin, T., and Dinney, C. P. (2002) Inhibition of angiogenesis by the antiepidermal growth factor receptor antibody ImClone C225 in androgen-independent prostate cancer growing orthotopically in nude mice, Clin. Cancer Res. 8, 1253-1264.
78. Hamilton, L. M., Torres-Lozano, C., Puddicombe, S. M., Richter, A., Kimber, I., Dearman, R. J., Vrugt, B., Aalbers, R., Holgate, S. T., Djukanovic, R., Wilson, S. J., and Davies, D. E. (2003) The Role of the Epidermal Growth Factor Receptor in Sustaining Neutrophil Inflammation in Severe Asthma, Clin. Exp. Allergy 33, 233-240.
79. MacNeil, D. J., Howard, A. D., Guan, X., Fong, T. M., Nargund, R. P., Bednarek, M. A., Goulet, M. T., Weinberg, D. H., Strack, A. M., Marsh, D. J., Chen, H. Y., Shen, C. P., Chen, A. S., Rosenblum, C. I., MacNeil, T., Tota, M., Maclntyre, E. D., and Van der Ploeg, L. H. (2002) The role of melanocortins in body weight regulation: opportunities for the treatment of obesity, Eur. J. Pharmacol. 450, 93-109.
80. Chow, D., Ho, J., Nguyen Pham, T. L., Rose-John, S., and Garcia, K. C. (2001) In vitro reconstitution of recognition and activation complexes between interleukin-6 and gp130, Biochemistry 40, 7593-7603.
81. Ancey, C., Menet, E., Corbi, P., Fredj, S., Garcia, M., Rucker-Martin, C., Bescond, J., Morel, F., Wijdenes, J., Lecron, J. C., and Potreau, D. (2003) Human cardiomyocyte hypertrophy induced in vitro by gp130 stimulation, Cardiovasc. Res. 59, 78-85.
82. Hirota, H., Yoshida, K., Kishimoto, T., and Taga, T. (1995) Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice, Proc. Natl. Acad. Sci. U.S.A. 92, 4862-4866.
83. Badache, A., and Hynes, N. E. (2001) Interleukin 6 inhibits proliferation and, in cooperation with an epidermal growth factor receptor autocrine loop, increases migration of T47D breast cancer cells, Cancer Res. 61, 383-391.
84. Zhou, H. M., Weskamp, G., Chesneau, V., Sahin, U., Vortkamp, A., Horiuchi, K., Chiusaroli, R., Hahn, R., Wilkes, D., Fisher, P., Baron, R., Manova, K., Basson, C. T., Hempstead, B., and Blobel, C. P. (2004) Essential role for ADAM19 in cardiovascular morphogenesis, Mol. Cell. Biol. 24, 96-104.