Aβ42 overproduction associated with structural changes in the catalytic pore of γ-secretase: Common effects of Pen-2 N-terminal elongation and fenofibrate

Journal of Biological Chemistry

Volumn 282, Issue 17, 2007, Pages 12388-12396

  Isoo, Noriko ^a,b   Sato, Chihiro ^a   Miyashita, Hiroyuki ^a   Shinohara, Mitsuru ^a   Takasugi, Nobumasa ^a   Morohashi, Yuichi ^a,c   Tsuji, Shoji ^b   Tomita, Taisuke ^a   Iwatsubo, Takeshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYLOID; MEMBRANE PROTEIN; NICASTRIN; PRESENILIN (PS);

CELL MEMBRANES; CONFORMATIONS; MEDICAL PROBLEMS; POLYSACCHARIDES; PROTEINS; WATER;

ENZYME KINETICS;

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; FENOFIBRATE; GAMMA SECRETASE; PEN 2 PROTEIN; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); ANTILIPEMIC AGENT; MULTIPROTEIN COMPLEX; PEPTIDE FRAGMENT; SECRETASE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ASSAY; GENE EXPRESSION SYSTEM; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; REDUCTION; WATER PERMEABILITY; ANIMAL; BIOSYNTHESIS; CELL LINE; DROSOPHILA; DRUG EFFECT; ENZYME ACTIVATION; METABOLISM; MOUSE; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANTILIPEMIC AGENTS; CELL LINE; DROSOPHILA; ENZYME ACTIVATION; MICE; MULTIPROTEIN COMPLEXES; PEPTIDE FRAGMENTS; PROCETOFEN; PROTEIN STRUCTURE, TERTIARY;

EID: 34250336128     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M611549200     Document Type: Article

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