TMP21 is a presenilin complex component that modulates γ-secretase but not ε-secretase activity

Nature

Volumn 440, Issue 7088, 2006, Pages 1208-1212

  Chen, Fusheng ^a   Hasegawa, Hiroshi ^a,h   Schmitt Ulms, Gerold ^a   Kawarai, Toshitaka ^a,i   Bohm, Christopher ^a   Katayama, Taiichi ^a   Gu, Yongjun ^a   Sanjo, Nobuo ^a,j   Glista, Michael ^a   Rogaeva, Ekaterina ^a   Wakutani, Yosuke ^a   Pardossi Piquard, Raphaëlle ^a   Ruan, Xueying ^a   Tandon, Anurag ^a   Checler, Frédéric ^b   Marambaud, Philippe ^c,d   Hansen, Kirk ^e,f   Westaway, David ^a   St George Hyslop, Peter ^a,g   Fraser, Paul ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d Institute for Medical Research at North Shore LIJ   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF COLORADO   (United States)

^g TORONTO WESTERN HOSPITAL   (Canada)

^h SHIGA UNIVERSITY   (Japan)

ⁱ Brain and Heart Centre   (Japan)

^j TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CELLS; ENZYME KINETICS; YEAST;

MEMBRANE-BOUND PROTEIN; PRESENILIN COMPLEXES; PRESENILIN PROTEINS; SECRETASE ACTIVITY;

ENZYMES;

CADHERIN; EPSILON SECRETASE; GAMMA SECRETASE; NICASTRIN; NOTCH1 RECEPTOR; PRESENILIN 1; UNCLASSIFIED DRUG;

CELL ORGANELLE; COMPLEXATION; ENZYME ACTIVITY; STOICHIOMETRY; YEAST;

ANIMAL TISSUE; ARTICLE; COMPLEX FORMATION; ENZYME ACTIVITY; ENZYME MODIFICATION; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MASS SPECTROMETRY; MEMBRANE BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SOLUBILIZATION; STOICHIOMETRY;

ANIMALIA; SPODOPTERA FRUGIPERDA;

EID: 33646369950     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature04667     Document Type: Article

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