Conserved residues in juxtamembrane region of the extracellular domain of nicastrin are essential for γ-secretase complex formation

Journal of Neurochemistry

Volumn 98, Issue 1, 2006, Pages 300-309

  Walker, Emily S ^a   Martinez, Maribel ^a   Wang, Jun ^a   Goate, Alison ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

secretase; Alzheimer's disease; Extracellular domain; Nicastrin

Indexed keywords

AMYLOID BETA PROTEIN; ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; GAMMA SECRETASE; MUTANT PROTEIN; NICASTRIN; PROTEIN; PROTEIN PEN 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN PROTEIN INTERACTION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANALYSIS OF VARIANCE; ANIMALS; ASPARTIC ENDOPEPTIDASES; BLOTTING, WESTERN; ELECTROPHORESIS, GEL, PULSED-FIELD; ENDOPEPTIDASES; FIBROBLASTS; HUMANS; IMMUNOPRECIPITATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; MUTANT PROTEINS; PLASMIDS; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; TRANSFECTION;

EID: 33745079263     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.03881.x     Document Type: Article

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