γ-Secretase Activity Is Present in Rafts but Is Not Cholesterol-Dependent

Biochemistry

Volumn 42, Issue 47, 2003, Pages 13977-13986

  Wada, Satoko ^a   Morishima Kawashima, Maho ^a   Qi, Yue ^a   Misono, Hiroaki ^a,c   Shimada, Yukiko ^b   Ohno Iwashita, Yoshiko ^b   Ihara, Yasuo ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^c STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASSAYS; BIOCHEMISTRY; CELL MEMBRANES; CHOLESTEROL; MUTAGENESIS;

OVARY CELLS;

ENZYMES;

AMYLOID BETA PROTEIN; CHOLESTEROL; GAMMA SECRETASE; METHYL BETA CYCLODEXTRIN; PROTEIN PRECURSOR;

ANIMAL CELL; ARTICLE; CELL ASSAY; CELL FRACTIONATION; CELL MEMBRANE; CHOLESTEROL METABOLISM; CONTROLLED STUDY; ENZYME ACTIVITY; HAMSTER; HUMAN; HUMAN CELL; MEMBRANE COMPONENT; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; NONHUMAN; OVARY CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN ISOLATION; PROTEIN PURIFICATION; PROTEIN STABILITY; REDUCTION;

AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANTICHOLESTEREMIC AGENTS; ASPARTIC ENDOPEPTIDASES; BACTERIAL TOXINS; BETA-CYCLODEXTRINS; BIOTINYLATION; CHO CELLS; CHOLESTEROL; CRICETINAE; CYCLODEXTRINS; ENDOPEPTIDASES; HEMOLYSIN PROTEINS; HUMANS; MEMBRANE MICRODOMAINS; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY; SOLUBILITY;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS;

EID: 0345275891     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034904j     Document Type: Article

References (60)

1. Vassar, R., Bennet, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., Luo, Y., Fisher, S., Fuller, J., Edenson, S., Lile, J., Jarosinski, M. A., Biere, A. L., Curran, E., Burgess, T., Louis, J. C., Collins, F., Treanor, J., Rogers, G., and Citron, M. (1999) Science 286, 735-741.
2. Gu, Y., Misonou, H., Sato, T., Dohmae, N., Takio, K., and Ihara, Y. (2001) J. Biol. Chem. 276, 35235-35238.
3. Sastre, M., Steiner, H., Fuchs, K., Capell, A., Multhaup, G., Condron, M. M., Teplow, D. B., and Haass, C. (2001) EMBO Rep. 9, 835-841.
4. Weidemann, A., Eggert, S., Reinhard, F. B., Vogel, M., Paliga, K., Baier, G., Masters, C. L., Beyreuther, K., and Evin, G. (2002), Biochemistry 41, 2825-2835.
5. Kimberly, W. T., Zheng, J. B., Guenette, S. Y., and Selkoe, D. J. (2001) J. Biol. Chem. 276, 40288-40292.
6. Takasugi, N., Tomita, T., Hayashi, I., Tsuruoka, M., Niimura, M., Takahashi, Y., Thinakaran, G., and Iwatsubo, T. (2003) Nature 422, 438-41.
7. Edbauer, D., Winkler, E., Regula, J. T., Pesold, B., Steiner, H., and Haass, C. (2003) Nat. Cell Biol. 5, 486-488.
8. Kimberly, W. T., LaVoie, M. J., Ostaszewski, B. L., Ye, W., Wolfe, M. S., and Selkoe, D. J. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 6382-6387.
9. Wolozin, B., Kellman, W., Rousseau, P., Celesis, G. G., and Siegel, G. (2000) Arch. Neurol. 57, 1439-1443.
10. Simons, M., Keller, P., De Strooper, B., Beyreuther, K., Dotti, C. G., and Simons, K. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 6460-6464.
11. Kojro, E., Gimpl, G., Lammich, S., Marz, W., and Fahrenholz, F. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 5815-5820.
12. Fassbender, K., Simons, M., Bergmann, C., Stroick, M., Lutjohann, D., Keller, P., Runz, H., Kuhl, S., Bertsch, T., von Bergmann, K., Hennerici, M., Beyreuther, K., and Hartmann, T. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 5856-5861.
13. Guy, R. K. (2000), Proc. Natl. Acad. Sci. U.S.A. 97, 7307-7312.
14. Waheed, A. A., Shimada, Y., Heijnen, H. F., Nakamura, M., Inomata, M., Hayashi, M., Iwashita, S., Slot, J. W., and Ohno-Iwashita, Y. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 4926-4931.
15. Qi, Y., Morishima-Kawashima, M., Sato, T., Mitsumori, R., and Ihara, Y. (2003) Biochemistry 42, 1042-1052.
16. Suzuki, N., Cheung, T. T., Cai, X. D., Odaka, A., Otvos, L., Jr., Eckman, C., Golde, T. E., and Younkin, S. G. (1994) Science 264, 1336-1340.
17. Tomita, S., Kirino, Y., and Suzuki, T. (1998) J. Biol. Chem. 273, 6277-6284.
18. Walter, J., Capell, A., Grunberg, J., Pesold, B., Schindzielorz, A., Prior, R., Podlisny, M. B., Fraser, P., Hyslop, P. S., Selkoe, D. J., and Haass, C. (1996) Mol. Med. 2, 673-691.
19. Morishima-Kawashima, M., and Ihara, Y. (1998) Biochemistry 37, 15247-15253.
20. Morishima-Kawashima, M., Osima, N., Ogata, H., Yamaguchi, H., Yoshimura, M., Sugihara, S., and Ihara, Y. (2000) Am. J. Pathol. 157, 2093-2099.
21. Iwamoto, M., Morita, I., Fukuda, M., Murota, S., Ando, S., and Ohno-Iwashita, Y. (1997) Biochim. Biophys. Acta 1327, 222-230.
22. Iwamoto, M., Ohno-Iwashita, Y., and Ando, S. (1990) Eur. J. Biochem. 194, 25-31.
23. Sato, T., Dohmae, N., Qi, Y., Kakuda, N., Misonou, H., Mitsumori, R., Maruyama, H., Koo, E. H., Haass, C., Takio, K., Morishima-Kawashima, M., Ishiura, S., and Ihara, Y. (2003) J. Biol. Chem. 278, 24294-24301.
24. Pitha, J., Irie, T., Sklar, P. B., and Nye, J. S. (1988) Life Sci. 43, 493-502.
25. Hansen, G. H., Immerdal, L., Thorsen, E., Niels-Christiansen, L. L., Nystrom, B. T., Demant, E. J., and Danielsen, E. M. (2001) J. Biol. Chem. 276, 32338-32344.
26. Lee, S. J., Liyanage, U., Bickel, P. E., Xia, W., Lansbury, P. T., Jr, and Kosik, K. S. (1998) Nat. Med. 4, 730-734.
27. Li, Y. M., Lai, M. T. Xu, M., Huang, Q., DiMuzio-Mower, J., Sardana M. K., Shi, X. P., Yin, K. C., Shafer, J. A., and Gardell, S. J. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 6138-6143.
28. Gkantiragas, I., Brugger, B., Stuven, E., Kaloyanova, D., Li, X. Y., Lohr, K., Lottspeich, F., Wieland, F. T., and Helms, J. B. (2001) Mol. Biol. Cell 12, 1819-1833.
29. Ehehalt, R., Keller, P., Haass, C., Thiele C., and Simons, K. (2003) J. Cell. Biol. 160, 113-123.
30. Ohno-Iwashita, Y., Iwamoto, M., Mitsui, K., Kawasaki, H., and Ahdo, S. (1986) Biochemistry 25, 6048-6053.
31. Mitsui, K., Sekiya, T., Nozawa, Y., and Hase, J. (1979) Biochim. Biophys. Acta 554, 68-75.
32. Rossjohn, J., Feil, S. C., McKinstry, W. J., Tweten, R. K., and Parker, M. W. (1997) Cell 89, 685-692.
33. Fujimoto, T., Hayashi, M., Iwamoto, M., and Ohno-Iwashita, Y. (1997) J. Histochem. Cytochem. 45, 1197-1205.
34. Hagiwara, H., Kogure, S. Y., Nakamura, M., Shimada, Y., Ohno-Iwashita, Y., and Fujimoto, T. (1999) Biochem. Biophys. Res. Commun. 260, 516-521.
35. Mobius, W., Ohno-Iwashita, Y., van Donselaar, E. G., Oorschot, V. M., Shimada, Y., Fujimoto, T., Heijnen, H. F., Geuze, H. J., and Slot, J. W. (2002) J. Histochem. Cytochem. 50, 43-55.
36. Keller, P., and Simons, K. (1998) J. Cell. Biol. 140, 1357-1367.
37. Kabouridis, P. S., Janzen, J., Magee, A. L., and Ley, S. C. (2000) Eur. J. Immunol. 30, 954-963.
38. Yamazaki, T., Chang, T. Y., Haass, C., and Ihara, Y. (2001) J. Biol. Chem. 276, 4454-4460.
39. Runz, H., Rietdorf, J., Tomic, I., de Bernard, M., Beyreuther, K., Pepperkok, R., and Hartmann, T. (2002) J. Neurosci. 22, 1679-1689.
40. Wahrle, S., Das, P., Nyborg, A. C., McLendon, C., Shoji, M., Kawarabayashi, T., Younkin, L. H., Younkin, S. G., and Golde, T. E. (2002) Neurobiol. Dis. 9, 11-23.
41. Greenfield, J. P., Tsai, J., Gouras, G. K., Hai, B., Thinakaran, G., Checler, F., Sisodia, S. S., Greengard, P., and Xu, H. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 742-747.
42. Xia, W., Ray, W. J., Ostaszewski, B. L., Rahmati, T., Kimberly, W. T., Wolfe, M. S., Zhang, J., Goate, A. M., and Selkoe, D. J. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 9299-9304.
43. Annaert, W. G., Levesque, L., Craessaerts, K., Dierinck, I., Snellings, G., Westaway, D., George-Hyslop, P. S., Cordell, B., Fraser, P., and De Strooper, B. (1999) J. Cell. Biol. 147, 277-294.
44. Cupers, P., Bentahir, M., Craessaerts, K., Orlans, I., Vanderstichele, H., Saftig, P., De Strooper, B., and Annaert, W. (2001) J. Cell. Biol. 154, 731-740.
45. Lai, M. T., Chen, E., Crouthamel, M. C., DiMuzio-Mower, J., Xu, M., Huang, Q., Price, E., Register, B., Shi, X. P., Donoviel, D. B., Berstein, A., Hazuda, D., Gardell, S. J., and Li, Y. M. (2003) J. Biol. Chem. 278, 22475-22481.
46. Kaether, C., Lammich, S., Edbauer, D., Ertl, M., Rietdorf, J., Capell, A., Steiner, H., and Haass, C. (2002) J. Cell. Biol. 158, 551-561.
47. De Strooper, B., Annaert, W., Cupers, P., Saftig, P., Craessaerts, K., Mumm, J. S., Schroeter, E. H., Schrijvers, V., Wolfe, M. S., Ray, W. J., Goate, A., and Kopan, R. (1999) Nature 398, 518-522.
48. Ni, C. Y., Murphy, M. P., Golde, T. E., and Carpenter, G. (2001) Science 294, 2179-2181.
49. Marambaud, P., Shioi, J., Serban, G., Georgakopoulos, A., Sarner, S., Nagy, V., Baki, L., Wen, P., Efthimiopoulos, S., Shao, Z., Wisniewski, T., and Robakis, N. K. (2002) EMBO J. 21, 1948-1956.
50. May, P., Reddy, Y. K., and Herz, J. (2002) J. Biol. Chem. 277, 18736-18743.
51. Lammich, S., Okochi, M., Takeda, M., Kaether, C., Capell, A., Zimmer, A. K., Edbauer, D., Walter, J., Steiner, H., and Haass, C. (2002) J. Biol. Chem. 277, 44754-44759.
52. Kim, D. Y., Ingano, L. A., and Kovacs, D. M. (2002) J. Cell. Biol. 277, 49976-49981.
53. Ikeuchi, T., and Sisodia, S. S. (2003) J. Biol. Chem. 278, 7751-7754.
54. Logeat, F., Bessia, C., Brou, C., LeBail, O., Jarriault, S., Seidah, N. G., and Israel, A. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 8108-8112.
55. Blaumueller, C. M., Qi, H., Zagouras, P., and Artavanis-Tsakonas, S. (1997) Cell 90, 281-291.
56. Mumm, J. S., Schroeter, E. H., Saxena, M. T., Griesemer, A., Tian, X., Pan, D. J., Ray, W. J., and Kopan, R. (2000) Mol. Cell 5, 197-206.
57. Brou, C., Logeat, F., Gupta, N., Bessia, C., LeBail, O., Doedens, J. R., Cumano, A., Roux, P., Black, R. A., and Israel, A. (2000) Mol. Cell 5, 207-216.
58. Nathke, I. S., Hinck, L., Swedlow, J. R., Papkoff, J., and Nelson, W. J. (1994) J. Cell. Biol. 125, 1341-1352.
59. Georgakopoulos, A., Marambaud, P., Efthimiopoulos, S., Shioi, J., Cui, W., Li, H. C., Schutte, M., Gordon, R., Holstein, G. R., Martinelli, G., Mehta, P., Friedrich, V. L., Jr., and Robakis, N. K. (1999) Mol. Cell 4, 893-902.
60. Murakami, D., Okamoto, I., Nagano, O., Kawano, Y., Tomita, T., Iwatsubo, T., De Strooper, B., Yumoto, E., and Saya, H. (2003) Oncogene 22, 1511-1516.