Notch and the amyloid precursor protein are cleaved by similar γ-secretase(s)

Biochemistry

Volumn 42, Issue 1, 2003, Pages 137-144

  Kimberly, W Taylor ^a   Esler, William P ^a   Ye, Wenjuan ^b   Ostaszewski, Beth L ^b   Gao, Jun ^a   Diehl, Thekla ^b   Selkoe, Dennis J ^b   Wolfe, Michael S ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFLICTS;

ANTIBODIES; SUBSTRATES;

PROTEINS;

AMINO ACID; AMYLOID PRECURSOR PROTEIN; ANTIBODY; ENZYME INHIBITOR; GAMMA SECRETASE; NOTCH RECEPTOR;

AMINO ACID SEQUENCE; ARTICLE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; REACTION ANALYSIS;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BINDING, COMPETITIVE; CHO CELLS; CRICETINAE; ENDOPEPTIDASES; HELA CELLS; HUMANS; HYDROLYSIS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; PEPTIDES; PRESENILIN-1; PRESENILIN-2; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, NOTCH; RECOMBINANT FUSION PROTEINS; SOLUBILITY; SUBSTRATE SPECIFICITY;

EID: 0037435604     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi026888g     Document Type: Article

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