RNA interference silencing of the adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Aβ generation

Journal of Biological Chemistry

Volumn 282, Issue 7, 2007, Pages 4318-4325

  Xie, Zhongcong ^a,b   Dong, Yuanlin ^a,b   Maeda, Uta ^a,b   Xia, Weiming ^a   Tanzi, Rudolph E ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE (AD) NEUROPATHOGENESIS; AMYLOID PRECURSOR PROTEIN (APP); BINDING DOMAINS; SECRETASE;

BINDING SITES; MOLECULAR INTERACTIONS; NEUROLOGY; PATHOGENS; RNA;

PROTEINS;

ADAPTOR PROTEIN; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; PROTEIN FE65; PROTEIN SHC; PROTEIN SHC A; PROTEIN SHC C; RNA; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN P3, HUMAN; AMYLOID BETA-PROTEIN P3, HUMAN; APBB1 PROTEIN, HUMAN; NERVE PROTEIN; NEUROPEPTIDE; NUCLEAR PROTEIN; SECRETASE; SHC3 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SMALL INTERFERING RNA; SRC HOMOLOGY 2 DOMAIN CONTAINING, TRANSFORMING PROTEIN 1; SRC HOMOLOGY 2 DOMAIN-CONTAINING, TRANSFORMING PROTEIN 1;

ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DOWN REGULATION; GENE SILENCING; GLIOMA CELL; HUMAN; HUMAN CELL; MOLECULAR BIOLOGY; MOLECULAR INTERACTION; MOLECULAR STABILITY; NEUROPATHOLOGY; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; REDUCTION; RNA INTERFERENCE; SENILE PLAQUE; SEQUENCE HOMOLOGY; BIOSYNTHESIS; COMPARATIVE STUDY; GENETICS; METABOLISM; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SPECIES DIFFERENCE; TUMOR CELL LINE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; CELL LINE, TUMOR; HUMANS; NERVE TISSUE PROTEINS; NEUROPEPTIDES; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; RNA INTERFERENCE; RNA, SMALL INTERFERING; SPECIES SPECIFICITY;

EID: 33947529531     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M609293200     Document Type: Article

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