Characterization of the reconstituted γ-secretase complex from Sf9 cells co-expressing presenilin 1, nacastrin, aph-1a, and pen-2

Biochemistry

Volumn 44, Issue 11, 2005, Pages 4450-4457

  Zhang, Lili ^a   Lee, Julie ^a   Song, Lixin ^a   Sun, Xiaoyan ^b   Shen, Jie ^b   Terracina, Giuseppe ^a   Parker, Eric M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CELLS; COMPLEXATION; DISEASES; MEMBRANES; MUTAGENESIS; SUBSTRATES;

CLEAVAGE SITES; COMPLEXES; INHIBITORS; PRECURSORS;

ENZYMES;

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; C99 PROTEIN; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; MEMBRANE PROTEIN; N160 PROTEIN; NACASTRIN; NOTCH RECEPTOR; PEN 2 PROTEIN; PRESENILIN 1; PROTEIN; PROTEIN APH 1A; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; APP GENE; ARTICLE; BACULOVIRUS; CELL STRAIN; CELL STRAIN 293; CELL STRAIN SF9; ENZYME ANALYSIS; ENZYME RECONSTITUTION; FAMILIAL DISEASE; GENE; GENE MUTATION; HUMAN; HUMAN CELL; INSECT CELL; MAMMAL CELL; MISSENSE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; VIRAL GENE DELIVERY SYSTEM;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BACULOVIRIDAE; CELL LINE; CELL MEMBRANE; CELLS, CULTURED; ENDOPEPTIDASES; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MICE; MICE, MUTANT STRAINS; MULTIPROTEIN COMPLEXES; MUTATION; PEPTIDE HYDROLASES; PRESENILIN-1; SPODOPTERA;

EID: 15544378384     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0481500     Document Type: Article

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