Monoubiquitination and endocytosis direct γ-secretase cleavage of activated Notch receptor

Journal of Cell Biology

Volumn 166, Issue 1, 2004, Pages 73-83

  Gupta Rossi, Neetu ^a   Six, Emmanuelle ^a   LeBail, Odile ^a   Logeat, Frédérique ^a   Chastagner, Patricia ^a   Olry, Annie ^a   Israël, Alain ^a   Brou, Christel ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

secretase; Endocytosis; Notch; Presenilins; Ubiquitin

Indexed keywords

BINDING PROTEIN; CLATHRIN; DELTA LIKE 1 PROTEIN; GAMMA SECRETASE; LIGAND; LYSINE; NOTCH RECEPTOR; PRESENILIN 1; PRESENILIN 2; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ENDOCYTOSIS; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROCESSING; REACTION ANALYSIS; UBIQUITINATION;

AMINO ACID SEQUENCE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CELL LINE; ENDOCYTOSIS; ENDOPEPTIDASES; HELA CELLS; HUMANS; IMMUNOBLOTTING; LIGANDS; LYSINE; MEMBRANE PROTEINS; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; PRECIPITIN TESTS; PRESENILIN-1; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, NOTCH; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION; UBIQUITIN;

ANIMALIA; ARACHNIDA; HEXAPODA; MAMMALIA;

EID: 3142704315     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200310098     Document Type: Article

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