Presenilin-1 affects trafficking and processing of βAPP and is targeted in a complex with nicastrin to the plasma membrane

Journal of Cell Biology

Volumn 158, Issue 3, 2002, Pages 551-561

  Kaether, Christoph ^a   Lammich, Sven ^a   Edbauer, Dieter ^a   Ertl, Michaela ^a   Rietdorf, Jens ^b   Capell, Anja ^a   Steiner, Harald ^a   Haass, Christian ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

Alzheimer's disease; Amyloid precursor protein; GFP; Nicastrin; Presenilin

Indexed keywords

AMYLOID BETA PROTEIN; ENDOGLYCOSIDASE H; GAMMA SECRETASE; N ACETYL BETA GLUCOSAMINIDASE; NICASTRIN; NOTCH RECEPTOR; PRESENILIN 1; PRESENILIN 2; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE; CELL SURFACE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EMBRYO; ENDOCYTOSIS; ENZYME ACTIVITY; ENZYME INACTIVATION; GENE DELETION; GOLGI COMPLEX; HUMAN; HUMAN CELL; INTERNALIZATION; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN TRANSPORT;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ACID; ASPARTIC ENDOPEPTIDASES; CELL COMPARTMENTATION; CELL MEMBRANE; CELLS, CULTURED; ENDOCYTOSIS; ENDOPEPTIDASES; EUKARYOTIC CELLS; GREEN FLUORESCENT PROTEINS; HUMANS; INDICATORS AND REAGENTS; LUMINESCENT PROTEINS; MACROMOLECULAR SUBSTANCES; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MUTAGENESIS, SITE-DIRECTED; MUTATION; PRESENILIN-1; PROTEIN BINDING; PROTEIN TRANSPORT; RECEPTORS, NOTCH; RECOMBINANT FUSION PROTEINS; TRANSFECTION;

EID: 0036327098     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200201123     Document Type: Article

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