Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Aβ-like peptide

Journal of Biological Chemistry

Volumn 277, Issue 47, 2002, Pages 44754-44759

  Lammich, Sven ^a   Okochi, Masayasu ^b   Takeda, Masatoshi ^b   Kaether, Christoph ^a   Capell, Anja ^a   Zimmer, Ann Katrin ^a   Edbauer, Dieter ^a   Walter, Jochen ^a   Steiner, Harald ^a   Haass, Christian ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESION; CELLS; MOLECULES; PROTEINS;

INTRAMEMBRANE PROTEOLYSIS;

BIOCHEMISTRY;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CELL PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR 4; GAMMA SECRETASE; HERMES ANTIGEN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; NOTCH RECEPTOR; PRESENILIN 1; UNCLASSIFIED DRUG; UVOMORULIN;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; GENE FUNCTION; GENE MUTATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANTIGENS, CD44; ASPARTIC ENDOPEPTIDASES; CARBAMATES; CELL LINE; CELL MEMBRANE; DIPEPTIDES; ENDOPEPTIDASES; ENZYME INHIBITORS; FIBROBLASTS; GAMMA-AMINOBUTYRIC ACID; HUMANS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; PEPTIDES; PRESENILIN-1; PRESENILIN-2; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRIGLYCERIDES;

ANIMALIA;

EID: 0347785491     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M206872200     Document Type: Article

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