FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a γ-secretase inhibitor: Evidence for direct involvement of PS1 in the γ-secretase cleavage complex

Neurobiology of Disease

Volumn 7, Issue 6, 2000, Pages 673-681

  Xia, Weiming ^a   Ostaszewski, Beth L ^a   Taylor Kimberly, W Taylor ^a   Rahmati, Talat ^a   Moore, Chad L ^b   Wolfe, Michael S ^a,b   Selkoe, Dennis J ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ASPARTIC PROTEINASE; GAMMA SECRETASE; PEPSTATIN; PRESENILIN 1;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CELL FREE SYSTEM; CONTROLLED STUDY; DRUG EFFICACY; ENZYME INHIBITION; FAMILIAL DISEASE; GENE MUTATION; IN VITRO STUDY; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS;

EID: 0034523058     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1006/nbdi.2000.0322     Document Type: Article

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