Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1

Nature

Volumn 405, Issue 6787, 2000, Pages 689-694

  Li, Yue Ming ^a   Xu, Min ^a   Lai, Ming Tain ^a   Huang, Qian ^a   Castro, José L ^b   DiMuzlo Mower, Jillian ^a   Harrison, Timothy ^b   Lellis, Colin ^a   Nadin, Alan ^b   Neduvelli, Joseph G ^b   Register, R Bruce ^a   Sardana, Mohinder K ^a   Shearman, Mark S ^b   Smith, Adrian L ^b   Shi, Xiao Ping ^a   Yin, Kuo Chang ^a   Shafer, Jules A ^a   Gardell, Stephen J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; ASPARTIC ACID; ASPARTIC PROTEINASE; BENZOPHENONE; ENZYME INHIBITOR; ENZYME PRECURSOR; GAMMA SECRETASE; PRESENILIN 1; PRESENILIN 2;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; EMBRYO; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MOUSE; MUTATION; NONHUMAN; PHOTOAFFINITY LABELING; PRIORITY JOURNAL;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; BINDING SITES; BIOTIN; ENDOPEPTIDASES; ENZYME INHIBITORS; HELA CELLS; HUMANS; MEMBRANE PROTEINS; PHOTOAFFINITY LABELS; PHOTOCHEMISTRY; PRESENILIN-1; PRESENILIN-2;

ANIMALIA;

EID: 0034621824     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35015085     Document Type: Article

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