Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 36, 2007, Pages 14489-14494

  Komatsu, Masaaki ^b,c,d   Qing, Jun Wang ^a,e   Holstein, Gay R ^a   Friedrich Jr , Victor L ^a   Iwata, Jun Ichi ^b,c   Kominami, Eiki ^c   Chait, Brian T ^e   Tanaka, Keiji ^b   Yue, Zhenyu ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^c JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^e ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Autophagosome; Axon; Axonopathy; Neurodegeneration; Purkinje cell

Indexed keywords

ATG7 PROTEIN; MEMBRANE PROTEIN; UNCLASSIFIED DRUG; ATG7 PROTEIN, MOUSE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; HEAT SHOCK PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; NEUROPEPTIDE; PCP2 PROTEIN, MOUSE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SQSTM1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATG7 GENE; AUTOPHAGY; CELL DEATH; DEGENERATIVE DISEASE; ELECTRON MICROSCOPY; GENE; HISTOLOGY; MEMBRANE STRUCTURE; MEMBRANE TRANSPORT; MOUSE; NERVE ENDING; NERVE FIBER; NERVE FIBER DEGENERATION; NEUROAXONAL DYSTROPHY; NEUROLOGIC DISEASE; NEUROPATHOLOGY; NONHUMAN; PHAGOSOME; PRIORITY JOURNAL; PROTEIN ANALYSIS; PURKINJE CELL; TRANSGENIC MOUSE; ANIMAL; CELL MEMBRANE; CELL SHAPE; CYTOLOGY; GENETICS; HOMEOSTASIS; METABOLISM; NERVE DEGENERATION; PATHOLOGY; REPORTER GENE; SPINE; TRANSMISSION ELECTRON MICROSCOPY;

MUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; AUTOPHAGY; AXONS; CELL MEMBRANE; CELL SHAPE; GENES, REPORTER; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HEAT-SHOCK PROTEINS; HOMEOSTASIS; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON, TRANSMISSION; MICROTUBULE-ASSOCIATED PROTEINS; NERVE DEGENERATION; NEUROPEPTIDES; PURKINJE CELLS; SPINE;

EID: 35448938087     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0701311104     Document Type: Article

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