Selected non-steroidal anti-inflammatory drugs and their derivatives target γ-secretase at a novel site: Evidence for an allosteric mechanism

Journal of Biological Chemistry

Volumn 279, Issue 42, 2004, Pages 43419-43426

  Beher, Dirk ^a,b   Clarke, Earl E ^a   Wrigley, Jonathan D J ^a   Martin, Agnes C L ^a   Nadin, Alan ^b   Churcher, Ian ^b   Shearman, Mark S ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; DERIVATIVES; DISEASES; ENZYMES; POLYPEPTIDES; SUBSTRATES;

ALZHEIMER'S DISEASE; ANTAGONISM; ANTI-INFLAMMATORY DRUGS;

DRUG PRODUCTS;

AMYLOID BETA PROTEIN[1-42]; FLURBIPROFEN; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; PROTEIN PRECURSOR; SULINDAC SULFIDE;

ALLOSTERISM; ARTICLE; BINDING SITE; CELL FREE SYSTEM; CONCENTRATION RESPONSE; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG BINDING; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVITY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME REGULATION; ENZYME SUBSTRATE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS;

ALLOSTERIC REGULATION; AMYLOID PRECURSOR PROTEIN SECRETASES; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BINDING SITES; ENDOPEPTIDASES; FLURBIPROFEN; KINETICS; LIGANDS; PEPTIDE FRAGMENTS; SULINDAC;

EID: 6344233805     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M404937200     Document Type: Article

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