Pharmacological knock-down of the presenilin 1 heterodimer by a novel γ-secretase inhibitor: Implications for presenilin biology

Journal of Biological Chemistry

Volumn 276, Issue 48, 2001, Pages 45394-45402

  Beher, Dirk ^a   Wrigley, Jonathan D J ^a   Nadin, Alan ^a   Evin, Geneviève ^b   Masters, Colin L ^b   Harrison, Timothy ^a   Castro, José L ^a   Shearman, Mark S ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC COMPOUNDS; DISEASES; ENZYME INHIBITION; ESTERS; GENES; PROTEINS;

ENDOPROTEOLYSIS;

BIOCHEMISTRY;

[1 BENZYL 4 [1 (5 CYCLOHEXYL 2 OXO 2,3 DIHYDRO 1 BENZO[E][1,4]DIAZEPIN 3 YLCARBAMOYL) S ETHYLCARBAMOYL] 2 HYDROXY 5 PHENYLPENTYL]CARBAMIC ACID TERT BUTYL ESTER; AMYLOID BETA PROTEIN; CARBAMIC ACID DERIVATIVE; ENZYME INHIBITOR; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; L 682679; L 685458; PRESENILIN 1; UNCLASSIFIED DRUG; COMPLEMENTARY DNA; MEMBRANE PROTEIN; PROTEINASE; S182 PROTEIN; SECRETASE;

ALZHEIMER DISEASE; ARTICLE; DRUG EFFECT; DRUG STRUCTURE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LONG TERM CARE; MISSENSE MUTATION; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PROCESSING; PROTEIN TRANSPORT; STRUCTURE ACTIVITY RELATION; ANIMAL; CELL CULTURE; CELL FRACTIONATION; CELL MEMBRANE; CENTRIFUGATION; CHEMISTRY; DIMERIZATION; DOSE RESPONSE; GENETIC TRANSFECTION; GENETICS; IC 50; KINETICS; METABOLISM; PHENOTYPE; PROTEIN BINDING; RAT; TIME; ULTRAVIOLET RADIATION;

ANIMAL; CELL MEMBRANE; CELLS, CULTURED; CENTRIFUGATION; DIMERIZATION; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPEPTIDASES; ENZYME INHIBITORS; HUMAN; INHIBITORY CONCENTRATION 50; KINETICS; MEMBRANE PROTEINS; MUTATION, MISSENSE; PHENOTYPE; PROTEIN BINDING; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBCELLULAR FRACTIONS; TIME FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED; ULTRAVIOLET RAYS;

EID: 0035977071     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M103075200     Document Type: Article

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