β-secretase cleavage at amino acid residue 34 in the amyloid β peptide is dependent upon y-secretase activity

Journal of Biological Chemistry

Volumn 278, Issue 23, 2003, Pages 21286-21294

  Shi, Xiao Ping ^a   Tugusheva, Katherine ^d   Bruce, James E ^b   Lucka, Adam ^d   Wu, Guo Xin ^d   Chen Dodson, Elizabeth ^d   Price, Eric ^d   Li, Yueming ^c   Xu, Min ^d   Huang, Qian ^d   Sardana, Mohinder K ^d   Hazuda, Daria J ^d  

^a MERCK RESEARCH LABORATORIES   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOLOGICAL MEMBRANES; CELLS; PROTEINS;

PEPTIDES;

BIOCHEMISTRY;

AMINO ACID; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ASPARTIC PROTEINASE; BETA SECRETASE; BETA SECRETASE 1; BETA SECRETASE 2; ENZYME INHIBITOR; GAMMA SECRETASE; MEMBRANE PROTEIN; PEPTIDE FRAGMENT; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONCENTRATION RESPONSE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; SENILE PLAQUE;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; CATHEPSIN D; CELL MEMBRANE; CELLS, CULTURED; CYTOPLASM; ENDOPEPTIDASES; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; KIDNEY; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY;

EID: 0037742239     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M209859200     Document Type: Article

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