Alzheimer's amyloid precursor protein α-secretase is inhibited by hydroxamic acid-based zinc metalloprotease inhibitors: Similarities to the angiotensin converting enzyme secretase

Biochemistry

Volumn 37, Issue 6, 1998, Pages 1680-1685

  Parvathy, S ^a   Hussain, Ishrut ^a   Karran, Eric H ^b   Turner, Anthony J ^a   Hooper, Nigel M ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; DIPEPTIDYL CARBOXYPEPTIDASE; METALLOPROTEINASE INHIBITOR;

ALZHEIMER DISEASE; ARTICLE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; PATHOGENESIS; PRIORITY JOURNAL; SENILE PLAQUE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ASPARTIC ENDOPEPTIDASES; DRUG SCREENING ASSAYS, ANTITUMOR; ENDOPEPTIDASES; ENZYME INHIBITORS; HUMANS; HYDROXAMIC ACIDS; METALLOENDOPEPTIDASES; MICROVILLI; NEUROBLASTOMA; PEPTIDYL-DIPEPTIDASE A; PHENYLALANINE; SWINE; TETRAZOLIUM SALTS; THIOPHENES; TUMOR CELLS, CULTURED; ZINC;

EID: 0032502033     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi972034y     Document Type: Article

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