γ-secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins

Biochemistry

Volumn 42, Issue 22, 2003, Pages 6664-6673

  Walsh, Dominic M ^a   Fadeeva, Julia V ^a   LaVoie, Matthew J ^a   Paliga, Krzysztof ^b   Eggert, Simone ^c   Kimberly, W Taylor ^a   Wasco, Wilma ^a   Selkoe, Dennis J ^a,d  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEGRADATION; DISEASES; ENZYMES; GENES;

NUCLEAR TRANSLOCATION;

PROTEINS;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; PROTEINASE;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME RELEASE; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN SECRETION; PROTEIN STABILITY; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CELL MEMBRANE; CELL NUCLEUS; CHO CELLS; CLONING, MOLECULAR; COS CELLS; CRICETINAE; ENDOPEPTIDASES; FLUORESCENT ANTIBODY TECHNIQUE, DIRECT; HUMANS; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0038322593     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi027375c     Document Type: Article

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