γ-Secretase activity is associated with a conformational change of Nicastrin

Journal of Biological Chemistry

Volumn 278, Issue 19, 2003, Pages 16474-16477

  Shirotani, Keiro ^a   Edbauer, Dieter ^a   Capell, Anja ^a   Schmitz, Julia ^a   Steiner, Harald ^a   Haass, Christian ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYST ACTIVITY; CONFORMATIONS; PROTEINS;

MUTATIONS;

BIOCHEMICAL ENGINEERING;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; ASPARTIC PROTEINASE; COMPLEMENTARY DNA; GAMMA SECRETASE; MONOCLONAL ANTIBODY; NICASTRIN; POLYCLONAL ANTIBODY; PRESENILIN 1; PRESENILIN 2; PROTEIN PEN 2; RNA; TRYPSIN; UNCLASSIFIED DRUG; BACE1 PROTEIN, HUMAN; MEMBRANE PROTEIN; NICASTRIN PROTEIN; PROTEINASE; SECRETASE;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CATALYSIS; EMBRYO; ENZYME ACTIVITY; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; KIDNEY CELL; MOUSE; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; PROTEIN DEGRADATION; SENILE PLAQUE; CELL LINE; CHEMISTRY; ENZYME ACTIVATION; METABOLISM; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

ANIMALIA;

AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; CELL LINE; ENDOPEPTIDASES; ENZYME ACTIVATION; HUMANS; MEMBRANE GLYCOPROTEINS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0038607071     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C300095200     Document Type: Article

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