γ-Secretase heterogeneity in the aph1 subunit: Relevance for alzheimer's disease

Science

Volumn 324, Issue 5927, 2009, Pages 639-642

  Serneels, Lutgarde ^a   Van Biervliet, Jérôme ^a   Craessaerts, Katleen ^a   Dejaegere, Tim ^a   Horré, Katrien ^a   Van Houtvin, Tine ^a   Esselmann, Hermann ^b,c   Paul, Sabine ^b,c   Schäfer, Martin K ^d   Berezovska, Oksana ^e   Hyman, Bradley T ^e   Sprangers, Ben ^a   Sciot, Raf ^a   Moons, Lieve ^f   Jucker, Mathias ^g   Yang, Zhixiang ^h   May, Patrick C ^h   Karran, Eric ^h,i   Wiltfang, Jens ^b,c   D'Hooge, Rudi ^a   De Strooper, Bart ^a   more..

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c UNIVERSITY OF DUISBURG ESSEN   (Germany)

^d PHILIPPS UNIVERSITY MARBURG   (Germany)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f SKELETAL BIOLOGY AND ENGINEERING RESEARCH CENTER   (Belgium)

^g UNIVERSITY OF TÜBINGEN   (Germany)

^h ELI LILLY AND COMPANY   (United States)

ⁱ JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; GAMMA SECRETASE; PRESENILIN; PROTEIN APH1A; PROTEIN APH1B; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA-PROTEIN (1-42); AMYLOID PRECURSOR PROTEIN; APH1B PROTEIN, HUMAN; APH1B PROTEIN, MOUSE; APH1C PROTEIN, MOUSE; MEMBRANE PROTEIN; NOTCH1 PROTEIN, MOUSE; NOTCH1 RECEPTOR; PEPTIDE FRAGMENT; PEPTIDE HYDROLASE; PRESENILIN 1; PROTEIN SUBUNIT; PROTEINASE; SECRETASE;

BRAIN; CANCER; DISEASE TREATMENT; PROTEIN;

ALZHEIMER DISEASE; ARTICLE; ENZYME ACTIVITY; ENZYME INACTIVATION; FAMILIAL DISEASE; GENETIC HETEROGENEITY; HUMAN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; ANIMAL; BRAIN; CHEMISTRY; DISEASE MODEL; DRUG ANTAGONISM; FEMALE; GENETICS; MAZE TEST; MEMORY; METABOLISM; MOUSE; NERVE CELL; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; ENDOPEPTIDASES; FEMALE; HUMANS; MAZE LEARNING; MEMBRANE PROTEINS; MEMORY; MICE; NEURONS; PEPTIDE FRAGMENTS; PEPTIDE HYDROLASES; PRESENILIN-1; PROTEIN SUBUNITS; RECEPTOR, NOTCH1; SIGNAL TRANSDUCTION;

EID: 65549140727     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1171176     Document Type: Article

References (25)

1. B. De Strooper et al., Nature 391, 387 (1998).
2. B. De Strooper, Neuron 38, 9 (2003).
3. S. S. Hebert et al., Neurobiol. Dis. 17, 260 (2004).
4. K. Shirotani, D. Edbauer, S. Prokop, C. Haass, H. Steiner, J. Biol. Chem. 279, 41340 (2004).
5. L. Serneels et al., Proc. Natl. Acad. Sci. U.S.A. 102, 1719 (2005).
6. G. Ma, T. Li, D. L. Price, P. C. Wong, J. Neurosci. 25, 192 (2005).
7. T. Dejaegere et al., Proc. Natl. Acad. Sci. U.S.A. 105, 9775 (2008).
8. A. V. Savonenko et al., Proc. Natl. Acad. Sci. U.S.A. 105, 5585 (2008).
9. C. Haass, D. J. Selkoe, Nat. Rev. Mol. Cell Biol. 8, 101 (2007).
10. D. Scheuner et al., Nat. Med. 2, 864 (1996).
11. K. Shirotani, M. Tomioka, E. Kremmer, C. Haass, H. Steiner, Neurobiol. Dis. 27, 102 (2007).
12. O. Berezovska et al., J. Neurosci. 25, 3009 (2005).
13. R. Radde et al., EMBO Rep. 7, 940 (2006).
14. K. K. Hsiao et al., Neuron 15, 1203 (1995).
15. D. L. King, G. W. Arendash, Physiol. Behav. 75, 627 (2002).
16. P. L. Pugh, J. C. Richardson, S. T. Bate, N. Upton, D. Sunter, Behav. Brain Res. 178, 18 (2007).
17. P. Hollingworth et al., J. Am. Geriatr. Soc. 54, 1348 (2006).
18. G. T. Wong et al., J. Biol. Chem. 279, 12876 (2004).
19. J. Tournoy et al., Hum. Mol. Genet. 13, 1321 (2004).
20. J. T. Siveke et al., Gastroenterology 134, 544 (2008).
21. A. Louvi, S. Artavanis-Tsakonas, Nat. Rev. Neurosci. 7, 93 (2006).
22. T. Kawai, N. Takagi, M. Nakahara, S. Takeo, Neurosci. Lett. 380, 17 (2005).
23. S. H. Choi, E. Norstrom, J. Neurosci. 27, 13579 (2007).
24. T. Li et al., J. Neurosci. 27, 10849 (2007).
25. We thank C. Peeters for assistance in pathological evaluations, C. Mathieu for FACS analysis, L. Van Aerschot for assistance with behavioral testing, S. Terclavers and H. Schieb for technical assistance, and A. Thathiah for proofreading the manuscript. This work was supported by a Pioneer award from the Alzheimer's Association; the Fund for Scientific Research Flanders (to R.D. and B.D.S.); KULeuven (Geconcerteerde onderzoeksacties); Federal Office for Scientific Affairs, Belgium; a Methusalem grant of the Flemish Government; MEMOSAD (F2-2007-200611) of the European Union; and NIH grants P01AG015379, R01AG026593, and AG026593 (to B.T.H.) and NIH AG 13579 (to B.T.H. and O.B.). B.D.S. is a paid consultant for Eli Lilly and Envivo Pharmaceuticals; B.T.H. is a paid consultant for Elan, Genentech, Pfizer, Takeda, Link, and Neurophage.