The carboxyl termini of β-amyloid peptides 1-40 and 1-42 are generated by distinct γ-secretase activities

Journal of Biological Chemistry

Volumn 271, Issue 45, 1996, Pages 28655-28659

  Klafki, H W ^a   Abramowski, D ^a   Swoboda, R ^b   Paganetti, P A ^b   Staufenbiel, M ^a  

^a Preclinical Research   (Switzerland)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; ENZYME ACTIVITY; ENZYME CONFORMATION; HUMAN; HUMAN CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; SEQUENCE ANALYSIS; STRUCTURE ACTIVITY RELATION;

AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; COS CELLS; CYSTEINE PROTEINASE INHIBITORS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOPEPTIDASES; GLYCOPROTEINS; HUMANS; LEUPEPTINS; PEPTIDE FRAGMENTS; TUMOR CELLS, CULTURED;

EID: 0029905596     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.45.28655     Document Type: Article

References (32)

1. Selkoe, D. J. (1994) Annu. Rev. Cell Biol. 10, 373-403
2. Esch, F. S., Keim, P. S., Beattie, E. C., Blacher, R. W., Culwell, A. R., Oltersdorf, T., McClure, D., and Ward, P. J. (1990) Science 248, 1122-1124
3. Weidemann, A., König, G., Bunke, D., Fischer, P., Salbaum, J. M., Masters, C. L., and Beyreuther, K. (1989) Cell 57, 115-126
4. Haass, C., Schlossmacher, M. G., Hung, A. Y., Vigo-Pelfrey, C., Mellon, A., Ostaszewski, B. L., Lieberburg, I., Koo, E. H., Schenk, D., Teplow, D. B., and Selkoe, D. J. (1992) Nature 359, 322-325
5. Shoji, M., Golde, T. E., Ghiso, J., Cheung, T. T., Estus, S., Schaffer, L. M., Cai, X.-D., McKay, D. M., Tintner, R., Frangione, B., and Younkin, S. G. (1992) Science 258, 126-129
6. Busciglio, J., Gabuzda, D. H., Matsudaira, P., and Yankner, B. A. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 2092-2096
7. Seubert, P., Vigo-Pelfrey, C., Esch, F., Lee, M., Dovey, H., Davis, D., Sinha, S., Schlossmacher, M., Whaley, J., Swindlehurst, C., McCormack, R., Wolfert, R., Selkoe, D., Lieberburg, I., and Schenk, D. (1992) Nature 359, 325-327
8. Mullan, M., Crawford, F., Axelman, K., Houlden, H., Lilius, L., Winblad, B., and Lannfelt, L. (1992) Nat. Genet. 1, 345-347
9. Citron, M., Oltersdorf, T., Haass, C., McConlogue, L., Hung, A. Y., Seubert, P., Vigo-Pelfrey, C., Lieberburg, I., and Selkoe, D. J. (1992) Nature 360, 672-674
10. Cai, X.-D., Golde, T. E., and Younkin, S. G. (1993) Science 259, 514-516
11. Citron, M., Vigo-Pelfrey, C., Teplow, D. B., Miller, C., Schenk, D., Johnston, J., Winblad, B., Venizelos, N., Lannfelt, L., and Selkoe, D. J. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 11993-11997
12. Johnston, J. A., Cowburn, R. F., Norgren, S., Wiehager, B., Venizelos, N., Winblad, B., Vigo-Pelfrey, C., Schenk, D., Lannfelt, L., and O'Neill, C. (1994) FEBS Lett. 354, 274-278
13. Evin, G., Beyreuther, K., and Masters, C. L. (1994) Amyloid: Int. J. Exp. Clin. Invest. 1, 263-280
14. Vigo-Pelfrey, C., Lee, D., Keim, P., Lieberburg, I., and Schenk, D. B. (1993) J. Neurochem. 61, 1965-1968
15. Dovey, H. F., Suomensaari-Chrysler, S., Lieberburg, I., Sinha, S., and Keim, P. S. (1993) Neuroreport 4, 1039-1042
16. Asami-Odaka, A., Ishibashi, Y., Kikuchi, T., Kitada, C., and Suzuki, N. (1995) Biochemistry 34, 10272-10278
17. Suzuki, N., Cheung, T. T., Cai, X.-D., Odaka, A., Otvos, L., Eckman, C., Golde, T. E., and Younkin, S. G. (1994) Science 264, 1336-1340
18. Tamaoka, A., Odaka, A., Ishibashi, Y., Usami, M., Sahara, N., Suzuki, N., Nukina, N., Mizusawa, H., Shoji, S., Kanazawa, I., and Mori, H. (1994) J. Biol. Chem. 269, 32721-32724
19. Jarret, J. T., Berger, E. P., and Lansbury, P. T. (1993) Biochemistry 32, 4693-4697
20. Miller, D. L., Papayannopoulos, I. A., Styles, J., Bobin, S. A., Lin, Y. Y., Biemann, K., and Iqbal, K. (1993) Arch. Biochem. Biophys. 301, 41-52
21. Roher, A. E., Lowenson, J. D., Clarke, S., Wolkow, C., Wang, R., Cotter, R. J., Reardon, I. M., Zürcher-Neely, H. A., Heinrikson, R. L., Ball, M. J., and Greenberg, B. D. (1993) J. Biol. Chem. 268, 3072-3083
22. Gravina, S. A., Ho, L., Eckman, C. B., Long, K. E., Otvos, L., Jr., Younkin, L. H., Suzuki, N., and Younkin, S. G. (1995) J. Biol. Chem. 270, 7013-7016
23. Iwatsubo, T., Odaka, A., Suzuki, N., Misuzawa, H., Nukina, N., and Ihara, Y. (1994) Neuron 13, 45-53
24. Higaki, J., Quon, D., Zhong, Z., and Cordell, B. (1995) Neuron 14, 651-659
25. Klafki, H.-W., Paganetti, P. A., Sommer, B., and Staufenbiel, M. (1995) Neurosci. Lett. 201, 29-32
26. Klafki H.-W., Wiltfang, J., and Staufenbiel, M. (1996) Anal. Biochem. 237, 24-29
27. Kozak, M. (1987) J. Mol. Biol. 196, 947-950
28. Andrä, K., Abramowski, D., Duke, M., Probst, A., Wiederhold, K.-H., Bürki, K., Goedert, M., Sommer, B., and Staufenbiel, M. (1996) Neurobiol. Aging 17, 183-190
29. Schrader-Fischer, G., and Paganetti, P. A. (1996) Brain Res. 716, 91-100
30. Chen, C., and Okayama, H. (1987) Mol. Cell. Biol. 7, 2745-2752
31. Palombella, V. J., Rando, O. J., Goldberg, A. L., and Maniatis, T. (1994) Cell 78, 773-785
32. Tsujinaka, T., Kajiwara, Y., Kambayashi, J., Sakon, M., Higuchi, N., Tanaka, T., and Mori, T. (1988) Biochem. Biophys. Res. Commun. 153, 1201-1208