Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

Nature

Volumn 441, Issue 7095, 2006, Pages 885-889

  Hara, Taichi ^a   Nakamura, Kenji ^b   Matsui, Makoto ^a,c,d   Yamamoto, Akitsugu ^e   Nakahara, Yohko ^b   Suzuki Migishima, Rika ^b   Yokoyama, Minesuke ^f   Mishima, Kenji ^g   Saito, Ichiro ^g   Okano, Hideyuki ^h,i   Mizushima, Noboru ^a,i  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b MITSUBISHI KAGAKU INSTITUTE OF LIFE SCIENCES   (Japan)

^c GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

^d NATIONAL INSTITUTE FOR BASIC BIOLOGY   (Japan)

^e NAGAHAMA INSTITUTE OF BIO SCIENCE AND TECHNOLOGY   (Japan)

^f NIIGATA UNIVERSITY   (Japan)

^g TSURUMI UNIVERSITY   (Japan)

^h KEIO UNIVERSITY   (Japan)

ⁱ JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIODIVERSITY; BIOMEDICAL ENGINEERING; CELLS; DEGRADATION; DISEASES; PROTEINS;

AUTOPHAGY; CYTOPLASMIC CONTENTS; DEGRADATION PROCESS; NEURODEGENERATIONS;

NEUROLOGY;

ADAPTATION; CYTOPLASM; DEGRADATION; DISEASE; NERVOUS SYSTEM DISORDER; PROTEIN; RODENT; STARVATION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; AUTOPHAGY RELATED 5 GENE; CELL INCLUSION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DEGENERATIVE DISEASE; GENE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MOTOR DYSFUNCTION; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN LOCALIZATION; TRANSGENIC MOUSE; UBIQUITINATION;

ANIMALS; AUTOPHAGY; BRAIN; CELL DEATH; INCLUSION BODIES; INTERMEDIATE FILAMENT PROTEINS; MICE; MICROTUBULE-ASSOCIATED PROTEINS; NERVE TISSUE PROTEINS; NEURODEGENERATIVE DISEASES; NEURONS; PURKINJE CELLS; UBIQUITIN;

EID: 33745192802     PISSN: 00280836     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/nature04724     Document Type: Article

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