The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons

Science

Volumn 323, Issue 5916, 2009, Pages 946-951

  Thathiah, Amantha ^a,b   Spittaels, Kurt ^c,f   Hoffmann, Marcel ^c,g   Staes, Mik ^c,h   Cohen, Adrian ^c,i   Horré, Katrién ^a,b   Vanbrabant, Mieke ^a,b   Coun, Frea ^b   Baekelandt, Veerle ^b   Delacourte, André ^e   Fischer, David F ^d   Pollet, Dirk ^c   De Strooper, Bart ^a,b   Merchiers, Pascal ^c,j  

^a Vlaams Institute for Biotechnology   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c GALAPAGOS NV   (Belgium)

^d BioFocus DPI   (United Kingdom)

^e JEAN PIERRE AUBERT RESEARCH CENTER   (France)

^f TIBOTEC BVBA   (Belgium)

^g Avantium Technologies BV   (Netherlands)

^h Terumo Europe NV   (Belgium)

ⁱ RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^j ABLYNX NV   (Belgium)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 3; GAMMA SECRETASE; NOTCH RECEPTOR; UNCLASSIFIED DRUG;

BRAIN; DISEASE; GENOMICS; NEUROLOGY; PEPTIDE; PROTEIN;

ALZHEIMER DISEASE; ANIMAL MODEL; ARTICLE; BRAIN; CELL SURFACE; CONTROLLED STUDY; ENZYME LOCALIZATION; FUNCTIONAL GENOMICS; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING;

ADULT; AGED; AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELL LINE; CELL LINE, TUMOR; CELLS, CULTURED; FEMALE; HUMANS; MALE; MICE; MIDDLE AGED; NEURONS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

EID: 60149093870     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1160649     Document Type: Article

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