RNA interference-mediated silencing of X11α and X11β attenuates amyloid β-protein levels via differential effects on β-amyloid precursor protein processing

Journal of Biological Chemistry

Volumn 280, Issue 15, 2005, Pages 15413-15421

  Xie, Zhongcong ^a,b   Romano, Donna M ^a,b   Tanzi, Rudolph E ^a,b  

^a MassGeneral Inst for Neurodeg Dis   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CELLS; DISEASES; ENZYMES; NEUROLOGY; RNA;

AMYLOID PRECURSOR PROTEIN (APP); NEUROGLIOMA CELLS; PROTEOLYSIS; RNAI SILENCING;

PROTEINS;

ADAPTOR PROTEIN; AMYLOID BETA PROTEIN; GAMMA SECRETASE; PROTEIN; PROTEIN X11ALPHA; PROTEIN X11BETA; RNA; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL LINE; CONTROLLED STUDY; ENZYME INHIBITION; GENE EXPRESSION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; GLIOMA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN PROCESSING; RNA INTERFERENCE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID MOTIFS; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; BLOTTING, WESTERN; CARRIER PROTEINS; CELL LINE, TUMOR; ELECTROPORATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE SILENCING; HUMANS; NERVE TISSUE PROTEINS; PROTEIN BINDING; RNA INTERFERENCE; RNA, SMALL INTERFERING; TIME FACTORS; TRANSFECTION;

EID: 17644409092     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M414353200     Document Type: Article

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