Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment γ: Evidence for distinct mechanisms involved in γ-secretase processing of the APP and Notch1 transmembrane domains

Journal of Biological Chemistry

Volumn 276, Issue 47, 2001, Pages 43756-43760

  Yu, Chunjiang ^a   Kim, Seong Hun ^a   Ikeuchi, Takeshi ^a   Xu, Huaxi ^b   Gasparini, Laura ^b   Wang, Rong ^b   Sisodia, Sangram S ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOLOGICAL MEMBRANES;

AMYLOID PRECURSOR PROTEINS (APP);

PROTEINS;

AMINO ACID; AMYLOID PRECURSOR PROTEIN; CELL PROTEIN; GAMMA SECRETASE; LEUCINE; MEMBRANE PROTEIN; NOTCH RECEPTOR; NOTCH1 RECEPTOR; PRESENILIN; PROTEIN S3; UNCLASSIFIED DRUG; VALINE; AMYLOID PRECURSOR PROTEIN CARBOXYL TERMINAL FRAGMENT GAMMA; AMYLOID PRECURSOR PROTEIN CARBOXYL-TERMINAL FRAGMENT GAMMA; PEPTIDE FRAGMENT; PRESENILIN 1; PRESENILIN 2; PROTEINASE; SECRETASE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROCESSING; AMINO ACID SEQUENCE; CELL LINE; CHEMISTRY; MASS SPECTROMETRY; METABOLISM; MOLECULAR GENETICS;

ANIMALIA;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; CELL LINE; ENDOPEPTIDASES; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PRESENILIN-1; PRESENILIN-2; PROTEIN PROCESSING, POST-TRANSLATIONAL; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 0035941278     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C100410200     Document Type: Article

References (38)

1. De Strooper, B., Saftig, P., Craessaerts, K., Vanderstichele, H., Guhde, G., Annaert, W., Von Figura, K., and Van Leuven, F. (1998) Nature 391, 387-390
2. Naruse, S., Thinakaran, G., Luo, J. J., Kusiak, J. W., Tomita, T., Iwatsubo, T., Qian, X., Ginty, D. D., Price, D. L., Borchelt, D. R., Wong, P. C., and Sisodia, S. S. (1998) Neuron 21, 1213-1221
3. De Strooper, B., Annaert, W., Cupers, P., Saftig, P., Craessaerts, K., Mumm, J. S., Schroeter, E. H., Schrijvers, V., Wolfe, M. S., Ray, W. J., Goate, A., and Kopan, R. (1999) Nature 398, 518-522
4. Selkoe, D. J. (2000) Curr. Opin. Neurobiol. 10, 50-57
5. Schroeter, E. H., Kisslinger, J. A., and Kopan, R. (1998) Nature 393, 382-386
6. Struhl, G., and Adachi, A. (1998) Cell 93, 649-660
7. Herreman, A., Serneels, L., Annaert, W. Collen, D., Schoonjans, L., and De Strooper, B. (2000) Nat. Cell Biol. 2, 461-462
8. Zhang, Z., Nadeau, P., Song, W., Donoviel, D., Yuan, M., Bernstein, A., and Yankner, B. A. (2000) Nat. Cell Biol. 2, 463-465
9. Li, Y. M., Xu, M., Lai, M. T., Huang, Q., Castro, J. L., DiMuzio-Mower, J., Harrison, T., Lellis, C., Nadin, A., Neduvelil, J. G., Register, R. B., Sardana, M. K., Shearman, M. S., Smith, A. L., Shi, X. P., Yin, K. C., Shafer, J. A., and Gardell, S. J. (2000) Nature 405, 689-694
10. Steiner, H., Kostka, M., Romig, H., Basset, G., Pesold, B., Hardy, J., Capell, A., Meyn, L., Grim, M. L., Baumeister, R., Fechteler, K., and Haass, C. (2000) Nat. Cell Biol. 2, 848-851
11. Evin, G., Sharples, R. A., Weidemann, A., Reinhard, F. B., Carbone, V., Culvenor, J. G., Holsinger, R. M., Sernee, M. F., Beyreuther, K., and Masters, C. L. (2001) Biochemistry 40, 8359-8368
12. Ray, W. J., Yao, M., Mumm, J., Schroeter, E. H., Saftig, P., Wolfe, M., Selkoe, D. J., Kopan, R., and Goate, A. M. (1999) J. Biol. Chem. 274, 36801-36807
13. Lah, J. J., and Levey, A. I. (2000) Mol. Cell. Neurosci. 16, 111-126
14. Schwarzman, A. L., Singh, N., Tsiper, M., Gregori, L., Dranovsky, A., Vitek, M. P., Glabe, C. G., St. George-Hyslop, P. H., and Goldgaber, D. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 7932-7937
15. Annaert, W. G., Levesque, L., Craessaerts, K., Dierinck, I., Snellings, G., Westaway, D., George-Hyslop, P. S., Cordell, B., Fraser, P., and De Strooper, B. (1999) J. Cell Biol. 147, 277-294
16. Cupers, P., Bentahir, M., Craessaerts, K., Orlans, I., Vanderstichele, H., Saftig, P., De Strooper, B., and Annaert, W. (2001) J. Cell Biol., 154, 731-740
17. Koo, E. H., and Squazzo, S. L. (1994) J. Biol. Chem. 269, 17386-17389
18. Struhl, G., and Adachi, A. (2000) Mol. Cell 6, 625-636
19. Murphy, M. P., Hickman, L. J., Eckman, C. B., Uljon, S. N., Wang, R., and Golde, T. E. (1999) J. Biol. Chem. 274, 11914-11923
20. Lichtenthaler, S. F., Wang, R., Grimm, H., Uljon, S. N., Masters, C. L., and Beyreuther, K. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 3053-3058
21. Martys-Zage, J. L., Kim, S. H., Berechid, B., Bingham, S. J., Chu, S., Sklar, J., Nye, J., and Sisodia, S. S. (2000) J. Mol. Neurosci. 15, 189-204
22. Sisodia, S. S., Koo, E. H., Hoffman, P. N., Perry, G., and Price, D. L. (1993) J. Neurosci. 13, 3136-3142
23. Lamb, B. T., Bardel, K. A., Kulnane, L. S., Anderson, J. J., Holtz, G., Wagner, S. L., Sisodia, S. S., and Hoeger, E. J. (1999) Nat. Neurosci. 2, 695-697
24. Smart, E. J., Ying, Y. S., Mineo, C., and Anderson, R. G. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 10104-10108
25. Shearman, M. S., Beher, D., Clarke, E. E., Lewis, H. D., Harrison, T., Hunt, P., Nadin, A., Smith, A. L., Stevenson, G., and Castro, J. L. (2000) Biochemistry 39, 8698-8704
26. Wang, R., Sweeney, D., Gandy, S. E., and Sisodia, S. S. (1996) J. Biol. Chem. 271, 31894-31902
27. Wolfe, M. S., Xia, W., Ostaszewski, B. L., Diehl, T. S., Kimberly, W. T., and Selkoe, D. J. (1999) Nature 398, 513-517
28. Capell, A., Steiner, H., Romig, H., Keck, S., Baader, M., Grim, M. G., Baumeister, R., and Haass, C. (2000) Nat. Cell Biol. 2, 205-211
29. McLendon, C., Xin, T., Ziani-Cherif, C., Murphy, M. P., Findlay, K. A., Lewis, P. A., Pinnix, I., Sambamurti, K., Wang, R., Fauq, A., and Golde, T. E. (2000) FASEB J. 14, 2383-2386
30. Pinnix, I., Musunuru, U., Tun, H., Sridharan, A., Golde, T., Eckman, C., Ziani-Cherif, C., Onstead, L., and Sambamurti, K. (2001) J. Biol. Chem. 276, 481-487
31. Selkoe, D. J., and Wolfe, M. S. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 5690-5692
32. Sastre, M., Steiner, H., Fuchs, K., Capell, A., Multhaup, G., Condron, M. M., Teplow, D. B., and Haass, C. (2001) EMBO J. 2, 835-841
33. Gu, Y., Misonou, H., Sato, T., Dohmae, N., Takio, K., and Ihara, Y. J. (2001) J. Biol. Chem. 276, 35235-35238
34. Huppert, S. S., Le, A., Schroeter, E. H., Mumm, J. S., Saxena, M. T., Milner, L. A., and Kopan, R. (2000) Nature 405, 966-970
35. Brown, M. S., Ye, J., Rawson, R. B., and Goldstein, J. L. (2000) Cell 100, 391-398
36. Cao, X., and Sudhof, T. C. (2001) Science 293, 115-120
37. Kulic, L., Walter, J., Multhaup, G., Teplow, D. B., Baumeister, R., Romig, H., Capell, A., Steiner, H., and Haass, C. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 5913-5918
38. Petit, A. Bihel, F., Alves da Costa, C., Pourquie, O., Checler, F., and Kraus, J. L. (2001) Nat. Cell Biol. 3, 507-511