Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α

Nature

Volumn 385, Issue 6618, 1997, Pages 733-736

  Moss, Marcia L ^a   Jin, S L Catherine ^d   Milla, Marcos E ^e   Burkhart, William ^a   Carter, H Luke ^a   Chen, Wen Ji ^a   Clay, William C ^a   Didsbury, John R ^a   Hassler, Daniel ^a   Hoffman, Christine R ^a   Kost, Thomas A ^a   Lambert, Millard H ^a   Leesnitzer, M Anthony ^a   McCauley, Philip ^a   McGeehan, Gerard ^c   Mitchell, Justin ^a   Moyer, Mary ^a   Pahel, Gregory ^a   Rocque, Warren ^a   Overton, Laurie K ^e   Schoenen, Frank ^a   Seaton, Theresa ^b   Su, Jui Lan ^a   Warner, Janet ^a   Willard, Derril ^a   Becherer, J David ^a   more..

^a GLAXOSMITHKLINE   (United States)

^b DOW CORNING CORPORATION   (United States)

^c RPR   (United States)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NONE

Author keywords

[No Author keywords available]

Indexed keywords

DISINTEGRIN; DNA FRAGMENT; MATRIX METALLOPROTEINASE; METALLOPROTEINASE; TUMOR NECROSIS FACTOR ALPHA;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; BASE PAIRING; BINDING SITE; ENZYME PURIFICATION; ENZYME SPECIFICITY; ENZYME STRUCTURE; GENE EXPRESSION; INFLAMMATORY DISEASE; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROCESSING; PROTEIN PURIFICATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLEEN; SWINE; X RAY CRYSTALLOGRAPHY;

ADAM PROTEINS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL LINE; CLONING, MOLECULAR; CONSERVED SEQUENCE; DISINTEGRINS; HUMANS; MEMBRANE PROTEINS; METALLOENDOPEPTIDASES; MOLECULAR SEQUENCE DATA; PROTEIN PRECURSORS; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SWINE; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; SUS SCROFA;

EID: 8044250278     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/385733a0     Document Type: Article

References (25)

1. Vassalli, P. The pathophysiology of tumour necrosis factors. Annu. Rev. Immunol. 10, 411-452 (1992).
2. Decker, T., Lohmann-Matthes, M. L. & Gifford, G. E. Cell-associated tumor necrosis factor (TNF) as a killing mechanism of activated cytotoxic macrophages. J. mmuno. 138, 957-962 (1987).
3. Kriegler, M., Perez, C., DeFay, K., Albert, I. & Lu, S. D. A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF. Cell 53, 45-53 (1996).
4. Howard, L., Lu, X., Mitchell, S., Griffiths, S. & Glynn, P. Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types. Biochem. J. 317, 45-50 (1996).
5. Rooke, J., Pan, D., Xu, T. & Rubin, G. M. KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis. Science 273, 1227-1231 (1996).
6. Mohler, K. M. et al. Protection against a lethal dose of endotoxin by an inhibitor of tumor necrosis factor processing. Nature 370, 218-220 (1994).
7. Gearing, A. et al. Processing of tumor necrosis factor-α precursor by metalloproteases. Nature 370, 558-561 (1994).
8. Wolfsberg, T. G. & White, J. M. ADAMs in fertilization and development. Dev. Biol. 180, 389-401 (1996).
9. Gomis-Reuth, F. X. et al. Refined 2.0 angstrom x-ray crystal structure of the snake venom zinc-endopeptidase adamalysin II. Primary and tertiary structure determination, refinement, molecular structure and comparison with astacin, collagenase and thermolysin. J. Mol. Biol. 239, 513-544 (1994).
10. Van Wart, H. E. & Birkedal-Hansen, B. The cysteine switch: a principle of regulation of metalloprotease activity with potential applicability to the entire matrix metalloprotease gene family. Proc. Natl Acad. Sci USA 87, 5578-5581 (1990).
11. Grams, F., Huber, R., Kress, L. F., Moroder, L. & Bode, W. Activation of snake venom metalloproteases by a cysteine switch-like mechanism. FEBS Lett. 335, 76-80 (1993).
12. Shannon, J. D., Baramova, E. N., Bjarnason, J. B. & Fox, J. W. Amino acid sequence of a Crotalus atrox venom metalloprotease which cleaves type IV collagen and gelatin. J. Biol. Chem. 264, 11575-11583 (1989).
13. Zhou, Q., Dangelmaier, C. & Smith, J. B. The hemorrhagin catrocollastatin inhibits collagen-induced platelet aggregatin by binding to collagen via its disintegrin-like domain. Biochem. Biophys. Res. Commun. 219, 720-726 (1996).
14. Gould, R. J. et al. Disintegrins: a family of integrin inhibitory proteins from viper venoms. Proc. Soc. Exp. Biol. Med. 195, 168-171 (1990).
15. Weskamp, G., Kratzschmar, J., Reid, M. S. & Blobel, C. P. MDCO, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains. J. Cell Biol. 132, 717-726 (1996).
16. Suffys, P., Beyaert, R., Van Roy, F. & Fiers, W. Involvement of a serine protease in tumor necrosis factor-mediated cytotoxicity. Eur. J. Biochem. 178, 257-265 (1988).
17. Bennett, T. A., Lynam, E. B., Sklar, L. A. & Rogelj, S. Hydroxamate-based metalloprotease inhibitor blocks shedding of L-selectin adhesion molecule from leukocytes. Functional consequences for neutrophil aggregation. J. Immunol. 156, 3093-3097 (1996).
18. Mullberg, J. et al. A metalloprotease inhibitor blocks shedding of the IL-6 receptor and te p60 TNF receptor. J. Immunol. 155, 5198-5205 (1995).
19. Arribas, J. et al. Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprotease inhibitors. J. Biol Chem. 271, 11376-11382 (1996).
20. Crowe, P. D. et al. A metalloprotease inhibitor blocks shedding of the 80-kD TNF receptor and TNF processing in T lymphocytes. J. Exp. Med. 181, 1205-1208 (1995).
21. Moyer, M., Rose, D. & Burkhart, W. Elutin of proteins from polyacrylamide gels onto the HP sequencing column. in Techniques in Protein Chemistry (ed. Crabb, J.) 195-204 (Academic, San Diego, 1994).
22. Granados, R. R., Guoxun, L., Derksen, A. C. G. & McKenna, K. A. A new cell line from Trichoplusia ni (BTI-Tn-5BI-4) susceptible to Trichoplusia single enveloped nuclear polyhedrosis virus. J. Invert. Path. 64, 260-266 (1994).
23. Ziegler-Heitbrook, et al. Establishment of a human cell line (Mono Mac 6) with characteristics of mature monocytes. Int. J. Cander 41, 456-461 (1988).
24. Morris, S. A. et al. Inhibition of organ invasion by the matrix metalloprotease inhibitor batimastat (BB-94) in two human colon carcinoma metastasis models. Cancer Res. 55, 3629-3633 (1995).
25. O'Byren, E. M. et al. Oral administration of a matrix metalloprotease inhibitor, CGS 27023A, protects the cartilage proteoglycan matrix in a partial meniscectomy model of osteoarthritis in rabbits. Inflam. Res. 44 (suppl. 2), S117-S118 (1995).