Presenilin-dependent γ-secretase on plasma membrane and endosomes is functionally distinct

Biochemistry

Volumn 45, Issue 15, 2006, Pages 4907-4914

  Fukumori, Akio ^a   Okochi, Masayasu ^a   Tagami, Shinji ^a   Jiang, Jingwei ^a   Itoh, Naohiro ^a   Nakayama, Taisuke ^a   Yanagida, Kanta ^a   Ishizuka Katsura, Yoshiko ^a   Morihara, Takashi ^a   Kamino, Kojin ^a   Tanaka, Toshihisa ^a   Kudo, Takashi ^a   Tanii, Hisashi ^a   Ikuta, Akiko ^a   Haass, Christian ^b   Takeda, Masatoshi ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DISEASES; PH; PHYSIOLOGY; PLASMAS; PROTEINS;

INTRAMEMBRANE PROTEOLYSIS; PRESENILIN (PS); SUBCELLULAR LOCATION;

BIOLOGICAL MEMBRANES;

AMYLOID PRECURSOR PROTEIN; ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; GAMMA SECRETASE; NICASTRIN; PRESENILIN 1; TRANSFERRIN;

ALZHEIMER DISEASE; ARTICLE; AUTORADIOGRAPHY; CELL FREE SYSTEM; CELL MEMBRANE; CELL STRAIN HEK293; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; ENDOCYTOSIS; ENDOSOME; ENZYME ACTIVE SITE; HELA CELL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MASS SPECTROMETRY; PH; PRIORITY JOURNAL; PROTEIN DEGRADATION; SEQUENCE ANALYSIS;

AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; CELL MEMBRANE; CELLS, CULTURED; ENDOCYTOSIS; ENDOPEPTIDASES; ENDOSOMES; HUMANS; HYDROGEN-ION CONCENTRATION; KIDNEY; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; PRESENILIN-1;

EID: 33645937614     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi052412w     Document Type: Article

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