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Volumn 277, Issue 35, 2002, Pages 31499-31505

Linear non-competitive inhibition of solubilized human γ-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines

(9) Tian, Gaochao a,b Sobotka Briner, Cynthia D a,b Zysk, John a,b Liu, Xiaodong a,b Birr, Cynthia a,b Sylvester, Mark A a,b Edwards, Philip D a,b Scott, Clay D a,b Greenberg, Barry D a,b

a Department of Lead Discovery ^* (United States)

b ASTRAZENECA (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; ENZYMES; PATHOLOGY; PROTEINS;

TRANSITION STATE;

BIOCHEMISTRY;

AMYLOID BETA PROTEIN; ASPARTIC PROTEINASE; BENZODIAZEPINE DERIVATIVE; BETA SECRETASE; ENZYME INHIBITOR; GAMMA SECRETASE; L 685458; PEPSTATIN A METHYL ESTER; PEPSTATIN DERIVATIVE; SULFONAMIDE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; PRIORITY JOURNAL;

AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; BENZODIAZEPINES; BINDING SITES; CARBAMATES; DIPEPTIDES; ENDOPEPTIDASES; HUMANS; KINETICS; MODELS, MOLECULAR; PEPSTATINS; PROTEASE INHIBITORS; RECOMBINANT PROTEINS; SULFONAMIDES;

EID: 0037200036 PISSN: 00219258 EISSN: None Source Type: Journal
DOI: 10.1074/jbc.M112328200 Document Type: Article

Times cited : (145)

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