In vitro characterization of the presenilin-dependent γ-secretase complex using a novel affinity ligand

Biochemistry

Volumn 42, Issue 27, 2003, Pages 8133-8142

  Beher, Dirk ^a   Fricker, Michael ^a   Nadin, Alan ^a   Clarke E , Earl ^a   Wrigley, Jonathan D J ^a   Li, Yue Ming ^b,d   Culvenor, Janetta G ^c   Masters, Colin L ^c   Harrison, Timothy ^a   Shearman, Mark S ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b MERCK RESEARCH LABORATORIES   (United States)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; COMPLEXATION; ENZYME KINETICS; PROTEINS; SUBSTRATES;

LIGANDS;

BIOCHEMISTRY;

ASPARTIC PROTEINASE; DIPEPTIDE; GAMMA SECRETASE; LIGAND; NICASTRIN; PRESENILIN 1;

ARTICLE; BIOTINYLATION; COMPLEX FORMATION; ENZYME ANALYSIS; ENZYME ASSAY; ENZYME LOCALIZATION; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MOLECULAR PROBE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRECIPITATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; BLOTTING, WESTERN; ENDOPEPTIDASES; HUMANS; LIGANDS; MEMBRANE PROTEINS; PRESENILIN-1; PRESENILIN-2; SUBSTRATE SPECIFICITY; TUMOR CELLS, CULTURED;

EID: 0038503396     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034045z     Document Type: Article

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