L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid β-protein precursor γ-secretase activity

Biochemistry

Volumn 39, Issue 30, 2000, Pages 8698-8704

  Shearman, M S ^a   Beher, D ^a   Clarke, E E ^a   Lewis, H D ^a   Harrison, T ^a   Hunt, P ^a   Nadin, A ^a   Smith, A L ^a   Stevenson, G ^a   Castro, J L ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

[BENZYL[1 (CARBAMOYL 2 PHENYLETHYLCARBAMOYL) 3 METHYLBUTYLCARBAMOYL]HYDROXY 5 PHENYLPENTYL]CARBAMIC ACID TERT BUTYL ESTER; AMYLOID BETA PROTEIN; GAMMA SECRETASE; L 685458; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; DRUG SPECIFICITY; ENZYME INHIBITOR INTERACTION; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEINASE INHIBITION;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CARBAMATES; CELL LINE; CHO CELLS; CRICETINAE; DIPEPTIDES; ENDOPEPTIDASES; HUMANS; MOLECULAR CONFORMATION; MOLECULAR MIMICRY; MOLECULAR SEQUENCE DATA; PROTEASE INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 0034254585     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0005456     Document Type: Article

References (29)