Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Aβ 42/40 ratios

Journal of Neurochemistry

Volumn 92, Issue 2, 2005, Pages 294-301

  Walker, Emily S ^a   Martinez, Maribel ^a   Brunkan, Anne L ^a   Goate, Alison ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

secretase; A ; Familial Alzheimer's disease; Presenilin 2; TM5

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; NOTCH RECEPTOR; PRESENILIN 1; PRESENILIN 2;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DNA POLYMORPHISM; GENE EXPRESSION; GENE MUTATION; GENETIC ASSOCIATION; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; CELL LINE; FIBROBLASTS; HUMANS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MUTATION; PEPTIDE FRAGMENTS; PRESENILIN-1; PRESENILIN-2; PROTEIN PROCESSING, POST-TRANSLATIONAL; TRANSFECTION;

ANIMALIA;

EID: 13244299288     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2004.02858.x     Document Type: Article

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